Recall that viruses need to infect a host cell to use their DNA copy machinery in order to replicate their own viral DNA (i.e. think of all the enzymes we talked about in lecture that are involved in DNA replication). The drug dideoxycytidine, used to treat certain viral infections, is a nucleotide made with 2,3'-dideoxyribose. This sugar lacks -OH groups at both the 2' and 3' positions. Explain why this drug will stop the growth of a virus (be complete)? Xeroderma pigmentosum (XP) is a rare autosomal recessive disease in humans which the subject is extremely sensitive to sunlight, developing lesions in the skin after slight exposure. An experiment was conducted to figure out why XP patients were so sensitive by exposing a cell culture from XP patients and non-XP patients to doses of UV light. The cell culture from XP patients showed a much higher mortality rate than non-XP cultures exposed to the same dose. Immersing the cell cultures in a solution of marked nucleotides showed that the non-XP cells incorporated large amounts of marked nucleotides into their DNA during the UV exposure where the XP cells did not. From these results, what is the likely mechanism of XP cell sensitivity to sunlight? Explain your answer.

Answers

Answer 1

The drug dideoxycytidine is used in the treatment of certain viral infections because it will stop the growth of a virus. This is because the drug is a nucleotide made with 2,3'-dideoxyribose, a sugar that lacks -OH groups at both the 2' and 3' positions.

DNA polymerase, which is an enzyme that is critical for DNA replication, requires a hydroxyl group (-OH) at the 3' position of the sugar in order to add nucleotides to the growing strand. Since the dideoxycytidine lacks the 3' hydroxyl group, the virus' DNA polymerase cannot add any additional nucleotides to the growing strand, and the replication of the viral DNA stops. As a result, the virus is unable to replicate its DNA, which will lead to the stoppage of the growth of the virus. Xeroderma pigmentosum (XP) is a rare autosomal recessive disease in humans in which the subject is extremely sensitive to sunlight and develops skin lesions after slight exposure.

Immersing the cell cultures in a solution of marked nucleotides showed that the non-XP cells incorporated large amounts of marked nucleotides into their DNA during the UV exposure where the XP cells did not .From these results, the most likely mechanism of XP cell sensitivity to sunlight is that XP cells have a defect in the ability to repair DNA damage caused by exposure to ultraviolet light. UV light causes a type of DNA damage known as pyrimidine dimers. Normally, DNA repair enzymes are able to recognize and fix this type of damage. However, in individuals with XP, these repair mechanisms are defective, making it difficult for them to repair the DNA damage caused by UV light.  

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Related Questions

In a herd of 1000 cows, each with one calf, weaning weight was recorded as a selection criterion.
The mean values for bull and heifer calves were 300 Kg and 250 Kg respectively, and the standard
deviation wasσP= 50Kg in each sex. What would you expect to be the weight of the heaviest bull?
Select one:
a. 365 Kg
b. 459 Kg
c. 388 Kg
d. 350 Kg
e. 400 Kg

Answers

The expected weight of the heaviest bull calf in a herd of 1000 cows, each with one calf, can be estimated by considering the mean values and standard deviation of weaning weights. The expected weight of the heaviest bull calf would be approximately 459 Kg.

To estimate the weight of the heaviest bull calf, we can use the concept of standard deviation. Since the standard deviation is the measure of variability or spread of data, we can expect that most of the bull calves' weights will fall within one standard deviation of the mean. Given that the mean weight of bull calves is 300 Kg and the standard deviation is 50 Kg, we can estimate that approximately 68% of the bull calves will have weights between 250 Kg (mean - 1 standard deviation) and 350 Kg (mean + 1 standard deviation). However, we are interested in the weight of the heaviest bull calf. Assuming a normal distribution of weights, we can estimate that the weight of the heaviest bull calf would be approximately 459 Kg, which is two standard deviations above the mean (300 Kg + 2 * 50 Kg).

Therefore, the correct answer is option b. 459 Kg.

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Ganglionic neurons of the autonomic nervous system will innervate all of the following targets, but NOT the ______ a. adipose tissue b. cardiac muscle c. glands d. skeletal muscles e. smooth muscle

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Ganglionic neurons of the autonomic nervous system will innervate all of the following targets, but NOT the skeletal muscles. Therefore, the correct answer is option d. Skeletal Muscles.

Ganglionic neurons of the autonomic nervous system innervate various targets, including adipose tissue, cardiac muscle, glands, and smooth muscle.

However, they do not directly innervate skeletal muscles. Skeletal muscles are primarily innervated by somatic motor neurons, which are part of the somatic nervous system.

The autonomic nervous system is responsible for regulating involuntary bodily functions such as heart rate, digestion, etc.... It consists of two main divisions: the sympathetic and parasympathetic divisions.

Ganglionic neurons are an integral part of both divisions and transmit signals from the central nervous system to their respective target tissues.

While sympathetic ganglionic neurons primarily release norepinephrine, which activates fight-or-flight responses, and parasympathetic ganglionic neurons release acetylcholine, which promotes rest-and-digest responses, neither directly innervate skeletal muscles.

Instead, skeletal muscles receive motor innervation from somatic motor neurons originating in the spinal cord. This allows for voluntary control over skeletal muscle movements.

Therefore, the right answer is given by option d. Skeletal Muscles. The ganglionic neurons of autonomic nervous system will not innervate the skeletal muscles.

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Afferent describes a signal traveling: from the effector to the receptor from the receptor to the effector from the control center to the receptor from the control center to the effector from the rece

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Afferent describes a signal traveling from the receptor to the control center. The afferent pathway carries sensory information from the sensory receptor to the central nervous system (CNS), i.e., brain and spinal cord. This pathway is also called the sensory pathway or ascending pathway.

The afferent pathway is the pathway that transmits information from sensory receptors to the brain. This pathway is made up of two types of sensory neurons: first-order neurons and second-order neurons. First-order neurons are pseudounipolar and have their cell bodies located in the dorsal root ganglia or cranial nerve ganglia. These neurons have peripheral fibers that extend from the receptor to the spinal cord or brainstem.

Second-order neurons are found in the spinal cord, brainstem, or thalamus. They receive input from first-order neurons and send signals to the thalamus. These neurons also have fibers that cross over to the opposite side of the CNS from where they originated.The afferent pathway is responsible for conveying sensory information to the brain. This information can include touch, temperature, pain, and proprioception. The pathway also plays a crucial role in reflex arcs, which are rapid, automatic responses to certain stimuli.

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Determine Vmax and KM for this enzyme using the Lineweaver-Burk reciprocal plot. Plot the inhibitor data on the same graph. (Note: Pick your axes and scales carefully so that the lines may be extrapolated to the negative x intercept. It would be a good idea to draw the graph on scratch graph paper first, then do a clean finished copy.)

Answers

The Lineweaver-Burk reciprocal plot analysis indicates a Km value of 100 mM and a Vmax value of 10 min⁻¹ for the enzyme. The presence of an inhibitor reduces the Vmax to 20 min⁻¹, resulting in a 50% decrease in maximum velocity.

Here is the Lineweaver-Burk reciprocal plot for the enzyme:

1/V₀ (1/min) | 1/[S] (mM¹)

--------- | --------

0.100 | 10.00

0.050 | 5.00

0.025 | 2.50

0.0125 | 1.25

0.00625 | 0.625

The slope of this line is -0.1, so Km = 10/0.1 = 100 mM. The y-intercept is 0.1, so Vmax = 1/0.1 = 10 min⁻¹.

The inhibitor data is plotted on the same graph as the enzyme data. The inhibitor data shifts the line to the right, and the new y-intercept is 0.05, so Vmax' = 1/0.05 = 20 min-1. This means that the inhibitor has decreased the maximum velocity of the enzyme by 50%.

The following graph shows the Lineweaver-Burk reciprocal plot for the enzyme and the inhibitor:

1/V₀ (1/min) | 1/[S] (mM⁻¹)

--------- | --------

Enzyme | 0.100 | 10.00

Enzyme | 0.050 | 5.00

Enzyme | 0.025 | 2.50

Enzyme | 0.0125 | 1.25

Enzyme | 0.00625 | 0.625

Inhibitor | 0.100 | 15.00

Inhibitor | 0.050 | 7.50

Inhibitor | 0.025 | 3.75

Inhibitor | 0.0125 | 1.875

Inhibitor | 0.00625 | 0.9375

The y-intercept of the line for the enzyme is 0.1, which is the Vmax of the enzyme. The y-intercept of the line for the inhibitor is 0.05, which is the Vmax' of the enzyme in the presence of the inhibitor. The difference between these two values is 0.05, which is the decrease in the maximum velocity of the enzyme caused by the inhibitor.

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Determine whether a solid forms when solutions containing the following salts are mixed. If so, write the ionic equation and the net ionic equation. NaNO3(aq) and K2S(aq)

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When solutions of NaNO₃ and K₂S are mixed with each other, Na₂S is formed as solid precipitate. The net ionic equation for the reaction is: S ⁻²(aq) + 2K⁺(aq) → K₂S(s).

An ionic equation is a chemical equation that shows only the ions which participate in a chemical reaction. It is similar to a molecular equation, which expresses compounds as molecules, but the electrolytes in aqueous solution are expressed as dissociated ions. The ions that react together in solution and form new substances are shown in the equation, while the other ions that don’t participate are called spectator ions.

A net ionic equation is a simplified form of an ionic equation that cancels out the spectator ions, which appear on both sides of the reaction arrow. The net ionic equation only shows the ions that actually change during the reaction.

When NaNO₃ and K₂S solutions are combined, a solid precipitate of Na₂S does indeed form. The reaction can be represented by the following ionic equation:

Na+(aq) + NO₃ ⁻(aq) + 2K⁺(aq) + S⁻²(aq) → 2K⁺(aq) + S⁻²(aq) + 2Na⁺(aq) + NO₃⁻(aq)

The net ionic equation is derived by eliminating the spectator ions, which in this instance are Na+ and NO3-. Consequently, the net ionic equation for the reaction can be expressed as follows:

S ⁻²(aq) + 2K⁺(aq) → K₂S(s).

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The absolute refractory period is a brief time following an action potential when the membrane will not generate another action potential, even if exposed to a strong stimulus. The absolute refractory period is caused by: a) K+ channels opening too easily. b) Na+ channels not opening. c) Na+ channels opening too easily. d) K+ channels not opening.

Answers

The correct option is c) Na+ channels opening too easily.The absolute refractory period (ARP) is the interval after the firing of an action potential where the neuron is unresponsive to subsequent stimuli. This refractory period has been defined as a short period of time following an action potential in which the membrane cannot generate another action potential, regardless of the strength of the stimulus.

The refractory period is due to the fact that during depolarization, when the membrane potential becomes positive, the inactivation gates of the sodium channels close. These gates only reopen after the membrane potential becomes more negative again, or in other words, when repolarization occurs.The ARP is triggered when a sufficient quantity of Na+ channels inactivate during an action potential.

Because the inactivated channels cannot open, a new action potential cannot be generated and the neuron is refractory to new stimulation. The absolute refractory period is caused by Na+ channels opening too easily.Basically, the inactivation gate of the Na+ channels is responsible for the refractory period. After depolarization, the inactivation gate closes, and only reopens when the membrane potential returns to its resting state.

Until this happens, no matter how strong the stimulus is, the neuron will not respond to it.

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Consider the graphs. which of the factors does not explain why the proportion of deaths due to cancer and heart disease in the united states today is much higher than it was 1900. Multiple Choice a) Reduced incidence of en infectious disesse due to establishment of health depermerits. b) Reduced incidence of en infectious disease tue to establishment of municiple weter treetment c) Reduced incidence of an infectious disease due to deveropment of vaccines. d) Reduced incidence of an infectious disease due to an aging gkbel gopulation. e) Reduced incirance of an infectious disense due to use ot antibiotics.

Answers

The factor that does not explain why the proportion of deaths due to cancer and heart disease in the United States today is much higher than it was in 1900 is option (d) Reduced incidence of an infectious disease due to an aging global population.

This option is not a relevant factor to the incidence of cancer and heart disease. The option implies that the aging population can lead to a higher incidence of these diseases, but it does not explain why there is a higher proportion of deaths due to cancer and heart disease in the United States today compared to 1900. Options (a), (b), (c), and (e) are all relevant factors that can explain the incidence of these diseases.

For instance, the development of vaccines has significantly reduced the incidence of infectious diseases such as tuberculosis, measles, polio, and smallpox. This has led to a decline in deaths caused by these diseases, and as a result, people are living longer, which has led to an increase in the incidence of cancer and heart disease. Furthermore, the use of antibiotics has also led to a reduction in infectious diseases. So therefore the correct answer is (d) Reduced incidence of an infectious disease due to an aging global population.

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1. Is COVID trending to be a seasonal illness like the flu or is it trending to be a year-round disease that is endemic? Since we have had two years of it, if it is trending to be a seasonal illness, what seasons does it increase in? 2. Do you think that, in the US, we will ever reach herd immunity because of vaccinations and/or actual illness, so that we don't have to worry about getting COVID like we don't have to worry about measles, mumps, whooping cough, polio, small pox, etc., all of those things we are simply vaccinated for as children without a second thought? What are your final thoughts about COVID?

Answers

1) COVID-19 is trending towards being an endemic disease, meaning it is expected to persist in the population at relatively consistent levels over time.

2) Achieving herd immunity for COVID-19 is a complex and evolving topic. Vaccinations play a crucial role in building population immunity and reducing the severity of the disease.

1) COVID-19 is trending towards being an endemic disease, meaning it is expected to persist in the population at relatively consistent levels over time, rather than following a distinct seasonal pattern like the flu. While it is challenging to predict the future trajectory of the virus with certainty, current evidence suggests that COVID-19 will continue to circulate year-round, with potential fluctuations in cases influenced by factors such as population immunity, public health measures, and viral variants. It is worth noting that different regions may experience variations in the seasonal patterns of COVID-19 due to factors such as climate, population density, and human behavior.

2) Achieving herd immunity for COVID-19 is a complex and evolving topic. Vaccinations play a crucial role in building population immunity and reducing the severity of the disease. However, the concept of reaching complete eradication or eliminating COVID-19 entirely, similar to diseases such as measles or smallpox, is currently uncertain. The effectiveness and duration of vaccine-induced immunity, the emergence of new variants, and the global distribution and accessibility of vaccines are factors that can influence the attainment of herd immunity. Ongoing monitoring, vaccination efforts, and adherence to public health measures are necessary to mitigate the impact of COVID-19 and strive for population-level protection.

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Virus morphology does NOT include which of the following: a. Size b. Shape and symmetry c. Presence or absence of an envelope d. Presence or absence of spike proteins (peplomers) GO e. Host range

Answers

Virus morphology does NOT include the term "Host range."

A virus is a microscopic, infectious agent that replicates inside living cells of an organism. It may cause a range of illnesses, from mild to lethal, in humans, animals, and plants.

A virus is made up of a nucleic acid genome (DNA or RNA), enclosed in a protein shell known as a capsid, and occasionally, an outer envelope made of protein, lipids, and carbohydrates. Some viruses have spike proteins (peplomers) protruding from the envelope's surface, which play a significant role in the viral replication cycle.

Virus morphology is the study of the size, shape, and arrangement of viruses. It also looks at their physical structure and chemical composition. The following are the elements of virus morphology:

Size of the virusShape and symmetry of the virusPresence or absence of an envelopePresence or absence of spike proteins (peplomers)Host range (It is a term that refers to the range of species that a virus can infect)

The virus morphology does not include the term "Host range." Therefore, the correct answer is (E) Host range.

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How is a western blot different from co-immunoprecipitation?
What is required for both techniques?

Answers

Answer with explanation:

- Immunoprecipitation involves using antibodies and agarose beads to isolate a target protein from a solution, while western blotting (also known as immunoblotting) uses gel electrophoresis and an antibody probe to analyze proteins

Biomechanical evaluation of opening-wedge high tibial osteotomy with composite materials using finite-element analysis

Answers

The biomechanical evaluation of opening-wedge high tibial osteotomy with composite materials using finite-element analysis involves a computational modeling approach to assess the mechanical behavior and performance of the surgical procedure.

Finite-element analysis (FEA) is a numerical method that divides complex structures into smaller elements to simulate their behavior under different loads and conditions.

In this study, the focus is on evaluating the effectiveness of using composite materials in the context of opening-wedge high tibial osteotomy. The composite materials may include combinations of different materials, such as metals and polymers, to enhance the stability and strength of the osteotomy construct.

Through finite-element analysis, various parameters can be assessed, such as stress distribution, deformation patterns, and the overall biomechanical response of the osteotomy site. This evaluation helps in understanding the potential benefits and limitations of using composite materials in opening-wedge high tibial osteotomy, aiding in the optimization of surgical techniques and implant design.

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Nitrogen that needs to be excreted comes from the breakdown of: a. proteins b. carbohydrates c. lipids. d. nucleic acids
Dissipation of heat through movement of air over the body is: a. conduction b. evaporation c. radiation d. convection

Answers

The breakdown of nitrogenous compounds primarily comes from the breakdown of proteins. Therefore, the correct answer is: a. proteins.

Heat dissipation through the movement of air over the body is known as: b. evaporation.

1. a. Proteins are large molecules composed of amino acids, which are organic compounds containing nitrogen. When proteins are metabolized or broken down in the body, the nitrogen-containing amino groups are removed through a process called deamination.

During deamination, the amino group (-NH2) is converted into ammonia (NH3) or ammonium ions (NH4+), depending on the pH of the surrounding environment. Ammonia is toxic to cells and needs to be converted into a less toxic form for excretion.

In the liver, ammonia is converted into urea through a series of biochemical reactions known as the urea cycle. Urea is a water-soluble compound that is less toxic than ammonia. It is transported through the bloodstream to the kidneys, where it is filtered out of the blood and excreted in urine.

Therefore, the breakdown of proteins provides the primary source of nitrogen that needs to be excreted from the body, with urea being the main nitrogenous waste product. Other nitrogen-containing compounds, such as nucleic acids, also contribute to nitrogen excretion but to a lesser extent compared to proteins.

2. b. evaporation

Evaporation occurs when sweat or moisture on the skin's surface is converted into vapor, taking away heat from the body. The other options, conduction, radiation, and convection, refer to different mechanisms of heat transfer but do not specifically involve the movement of air over the body.

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4. Hydrogen and Chioride are secreted into the lumen 1,4,2,3 2,4,3,1 3,1,4,2 1,3,2,4 a lower pH during gastric digettion. a higher pH during eastric bigestion. decreased production of pepsinogen by chief cellis. increased protein digestion in the stomach. decreased gastrin production. Which of the following are inwotved in biskasicy roctabcisom? Stomach, Kidners, Spleen, Aaterof wixnts. Liver, Pancreas, Adrenal Glands, Luras. Spleen, Liver, Intestines, Kidiners Pancreas, Stomach, Kiáners, intestines Lungs, Adrenal glands, Liver, Kodneys

Answers

The sequence 1, 4, 2, 3 is the answer. A lower pH during gastric digestion. a higher pH during gastric bigestion. decreased production of pepsinogen by chief cells. increased protein digestion in the stomach. decreased gastrin production.

Hydrogen and chloride are secreted into the lumen at a lower pH during gastric digestion. The main function of the stomach in digestion is the denaturation and hydrolysis of proteins. The stomach has a unique environment due to the presence of hydrochloric acid, which is necessary to activate the protein-digesting enzyme pepsin.

In the stomach, a proton pump in the parietal cells of the stomach lining transports hydrogen ions into the lumen of the stomach in exchange for potassium ions that go into the cell. This pump is responsible for secreting hydrochloric acid and giving gastric juices their low pH. Hydrochloric acid is generated in the stomach by combining water, carbon dioxide, and chloride ions. The chloride ions come from the blood and combine with hydrogen ions in the parietal cells to create hydrochloric acid. The pH of the stomach is about 1.5-3.5.

The answer is 1, 4, 2, 3 in terms of the order of hydrogen and chloride secretions involved in gastric digestion.

The correct answer is the sequence 1, 4, 2, 3 in terms of the order of hydrogen and chloride secretions involved in gastric digestion.

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the etiologic agent of chickenpox is group of answer choices a) hhv-6. b) poxvirus. c) herpes zoster. d) herpes simplex. e) parvovirus.

Answers

The etiologic agent of chickenpox is the Varicella-zoster virus, which belongs to the Herpesviridae family of viruses. Chickenpox is an acute and highly infectious disease that primarily affects children, but it can occur in people of all ages.

The virus is transmitted via the respiratory route and produces a viremia, allowing the virus to infect multiple organs. After the virus enters the body, it has an incubation period of 14 to 21 days before the initial symptoms emerge. The characteristic symptom of chickenpox is a rash of small, itchy, fluid-filled blisters that eventually crust over and heal. Other symptoms may include fever, headache, malaise, and loss of appetite. The rash can spread to the face, limbs, and trunk. Antiviral drugs such as acyclovir can be used to treat chickenpox in people with weakened immune systems, newborns, and pregnant women. Vaccination against chickenpox is highly effective and is recommended for all children, adolescents, and adults who have not had the disease previously.

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Question 6 Which cell types can cause tumours in the central
nervous system? Name three examples and describe their effects on
central nervous system function

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There are several cell types that can cause tumours in the central nervous system (CNS), including astrocytes, oligodendrocytes, and ependymal cells. The effects of these tumours on CNS function can vary widely, depending on the location and size of the tumour.

Astrocytomas are the most common type of primary brain tumour. Astrocytes are star-shaped cells that provide structural support to neurons and help maintain the blood-brain barrier. When these cells become cancerous, they can form tumours that interfere with normal brain function.  

The symptoms of ependymomas can include headaches, nausea, vomiting, and changes in vision. In summary, there are several cell types that can cause tumours in the central nervous system (CNS), including astrocytes, are the oligodendrocytes, and ependymal cells. The effects of these tumours on CNS function can vary widely, depending on the location and size of the tumour. The three examples discussed above (astrocytomas, oligodendrogliomas, and ependymomas) can cause a range of symptoms, including headaches, seizures, cognitive impairment, and hydrocephalus.

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William P. has had pronounced diarrhea for more than a week as a result of having acquired salmonellosis, a bacterial intestinal infection, from improperly handled food. What effect has this prolonged diarrhea had on his fluid balance and acid-base balance? In what ways has William's body been trying to compensate for these imbalances?

Answers

The prolonged diarrhea due to salmonellosis may have caused significant effects on his fluid balance and acid-base balance. William's body has been trying to compensate for these imbalances by activating thirst sensation and curtailing urine output.

William P. is suffering from salmonellosis, a bacterial intestinal infection that has resulted in pronounced diarrhea for more than a week. The continuous fluid and electrolyte losses due to prolonged diarrhea can trigger dehydration and electrolyte imbalances, thereby hampering the fluid balance of his body. This fluid loss can generate a declined plasma volume, which in turn can cause a reduction in blood pressure. The decrease in blood pressure can abate the renal perfusion pressure and, as a result, decrease the glomerular filtration rate. This can cause the kidneys to reabsorb more sodium and water, leading to depleted urine output and an increased risk of developing hypernatremia.

The loss of bicarbonate ions due to diarrhea can cause metabolic acidosis. To compensate for metabolic acidosis, William's body tries to buffer the excess hydrogen ions by using the bicarbonate ions present in the blood. The kidneys excrete less bicarbonate ions and retain more hydrogen ions, which helps maintain the acid-base balance. Additionally, William's body may also amplify his respiratory rate to exhale more carbon dioxide, which can avail in reducing the acidity of the blood.

William's body also tries to compensate for the loss of fluids and electrolytes due to prolonged diarrhea. The thirst mechanism is activated, causing him to feel thirsty, and he may drink more water to replenish the fluids lost. Additionally, his body may shrink the urine output, retain more sodium and water, and heighten the reabsorption of electrolytes like sodium and potassium to maintain a healthy balance.

In summary, the prolonged diarrhea of William P. has given rise to a depletion of fluids and electrolytes, which can prompt imbalances in his fluid and acid-base balance. His body compensates by retaining more fluids and electrolytes, minimizing urine output, and augmenting respiration rate to buffer the excess hydrogen ions.

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Poor outcome of head injury in geriatrics is associated with which of the following: Select one: a. Pain b. Headache c. Loss of consciousness d. Vomiting 12. Poor outcome of head injury in geriatrics

Answers

The correct answer is c. Loss of consciousness.

Loss of consciousness is a significant predictor of poor outcome in head injury among geriatric patients. When an elderly person sustains a head injury and loses consciousness, it indicates a more severe injury and is often associated with a higher risk of complications and adverse outcomes. Loss of consciousness can result from traumatic brain injury, which can lead to cognitive impairment, functional decline, and increased mortality in the geriatric population.

Loss of consciousness is an indicator of the severity of the brain injury and often accompanies other significant symptoms, such as memory loss, confusion, and neurological deficits. Geriatric patients who suffer from loss of consciousness after a head injury are at a higher risk of complications and adverse outcomes compared to those who remain conscious.

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What effect would blocking voltage-gated calcium
channels at a cholinergic synapse have on synaptic
communication?

Answers

Blocking voltage-gated calcium channels at a cholinergic synapse would impair synaptic communication.

Voltage-gated calcium channels play a crucial role in synaptic transmission by mediating the entry of calcium ions into the presynaptic terminal. These calcium ions are necessary for the release of neurotransmitters, such as acetylcholine, from the presynaptic neuron.

By blocking voltage-gated calcium channels at a cholinergic synapse, the influx of calcium ions into the presynaptic terminal would be inhibited. As a result, the release of acetylcholine into the synaptic cleft would be significantly reduced. Acetylcholine is the neurotransmitter responsible for transmitting signals across cholinergic synapses.

Without sufficient release of acetylcholine, the postsynaptic neuron would receive fewer neurotransmitter molecules, leading to a decrease in synaptic communication. This disruption in synaptic transmission can result in impaired neuronal signaling and affect various physiological processes and functions regulated by cholinergic pathways.

In summary, blocking voltage-gated calcium channels at a cholinergic synapse would hinder the release of acetylcholine and subsequently impair synaptic communication.

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most scientists agree that bipedalism was the adaptation of some primate species to an environment of savanna. true false

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The given statement "Most scientists agree that bipedalism was the adaptation of some primate species to an environment of savanna." is false.

While there is ongoing debate and multiple hypotheses regarding the factors that led to the evolution of bipedalism in early hominins, the idea that bipedalism solely evolved as an adaptation to a savanna environment is not universally agreed upon by scientists.

The savanna hypothesis, proposed by some researchers, suggests that the transition to bipedalism occurred as a response to living in open grassland environments where the ability to walk upright would provide advantages such as better visibility, energy efficiency, and thermoregulation.

However, this hypothesis is just one of several proposed explanations and does not account for all aspects of the evolutionary history of bipedalism.

Other hypotheses propose alternative factors that contributed to the adoption of bipedalism, including arboreal adaptations, the need for efficient terrestrial locomotion in diverse habitats, carrying objects, accessing new food resources, or freeing the hands for tool use.

These hypotheses consider a combination of ecological, anatomical, and behavioral factors that influenced the evolution of bipedalism in early hominins.

Overall, the evolution of bipedalism is a complex and multifaceted topic, and scientists continue to explore and refine our understanding of the various factors that led to this significant adaptation in human evolutionary history.

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EPILOGUE We have traced major events in the development of physical, social, and cognitive growth throughout the life span. Clearly, people change throughout their lives. As we explored each area of development, we encountered anew the nature-nurture issue, concluding in every significant instance that both nature and nurture contribute to a person's development of skills, personality, and interactions. Specifically, our genetic inheritance-nature-lays down general boundaries within which we can advance and grow; our environment-nurture-helps determine the extent to which we take advantage of our potential. Before proceeding to the next set of modules, turn to the prologue of this chapter, which discussed Elizabeth Carr and Louise Brown, who were born using in-vitro fertilization (IVF). Using your knowledge of human development, consider the following questions. 1. At one time, IVF commonly involved the implantation of multiple embryos at once in order to maximize the likelihood that at least one would develop. Sometimes that strategy resulted in multiple births. Would such newborns likely be identical twins? Why or why not? 2. Which kind of abnormalities might Elizabeth Carr and Louise Brown have been tested for as newborns? Page 363

Answers

No, newborns resulting from implantation of multiple embryos at once in IVF would not necessarily be identical twins because each embryo develops from a different egg and is fertilized by a different sperm.

1. This means that each embryo has its unique genetic makeup, and thus, would result in fraternal twins, triplets, quadruplets, etc., rather than identical twins.

2. Elizabeth Carr and Louise Brown might have been tested for chromosomal abnormalities such as Down syndrome and other genetic disorders that could be associated with the use of IVF. They might have also been tested for structural defects such as heart and other organ defects, neural tube defects, and limb abnormalities to ensure that their physical and cognitive development was on track.

Additionally, they might have been screened for infectious diseases and other illnesses that could impact their overall health and well-being.

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The term IVF commonly refers to the fertilization of an egg and sperm outside of the human body, in the laboratory, and the subsequent transfer of the fertilized embryo(s) into the uterus of the mother. If multiple embryos are implanted at once to increase the likelihood that at least one of them will develop, such newborns would not likely be identical twins because each embryo forms from a different .

sperm and egg and thus, is genetically distinct from the others.  In-vitro fertilization (IVF) has given birth to numerous babies with abnormalities.

Therefore, Elizabeth  and Louise Brown may have been tested for the following abnormalities as newborns:  Heart defects Congenital anomalies of the brain, spine, and spinal cord Blood diseases such as sickle cell anemia Cystic fibrosis is a disease that affects the lungs and digestive system.

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Characteristics exhibited by continuously varying traits include ________.
A. sex-linked genes only
B. autosomal genes only
C. quantification by measuring, weighing, counting, etc.
D. a 9:3:3:1 ratio
E. 3:1 and 1:1 ratios

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Characteristics exhibited by continuously varying traits include option(c) quantification by measuring, weighing, counting, etc.

Characteristics exhibited by continuously varying traits including height, weight, blood pressure, and skin colour are typically quantifiable and are influenced by multiple genes and environmental factors, resulting in a wide range of possible values rather than discrete categories.

The other options mentioned in the question are not applicable to continuously varying traits:

A. Sex-linked genes only: Continuous traits are not limited to being controlled exclusively by genes located on sex chromosomes.

B. Autosomal genes only: Continuous traits can be influenced by genes located on both autosomes and sex chromosomes.

D. A 9:3:3:1 ratio: This ratio is associated with the segregation of alleles in a dihybrid cross involving two genes with independent assortment. It is not directly related to continuously varying traits.

E. 3:1 and 1:1 ratios: These ratios are associated with Mendelian inheritance patterns, specifically the segregation of alleles in monohybrid crosses. They are not directly related to continuously varying traits.

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determine whether each factor would increase or decrease the rate of diffusion.

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Diffusion refers to the process by which molecules move from a region of high concentration to a region of low concentration. A few factors influence the rate of diffusion.

These factors are:

Temperature: The magnitude of the concentration gradientMolecular weightSurface areaViscosityTemperature: An increase in temperature would increase the rate of diffusion.

Temperature results in an increase in molecular motion, which raises the probability of molecular collision.The magnitude of the concentration gradient: A significant concentration gradient results in a greater rate of diffusion.

The greater the difference between the two areas' concentration, the greater the diffusion rate. Molecular weight: The lighter the molecule, the greater its rate of diffusion. Larger molecules move at a slower rate because their mass slows them down.

Surface area: As the surface area increases, so does the rate of diffusion. This is due to the greater space available for the molecules to diffuse.Viscosity: An increase in viscosity would decrease the rate of diffusion. Molecules find it challenging to move through a more viscous medium.

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2. Please classify the RNA species involved in protein translation, and summarize roles in protein biosynthesis ( 20 points).

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RNA plays an important role in protein biosynthesis. There are four main types of RNA involved in the protein translation process: messenger RNA (mRNA), transfer RNA (tRNA), ribosomal RNA (rRNA), and small nuclear RNA (snRNA).

Messenger RNA is responsible for carrying genetic information from DNA to the ribosomes, where proteins are synthesized. It is transcribed from DNA templates and contains codons that code for specific amino acids. Transfer RNA is involved in the actual translation of mRNA codons. It matches the correct amino acid to its corresponding codon and carries the molecules to the ribosome.

Ribosomal RNA (rRNA) is the most abundant kind of RNA and makes up the ribosome. It helps to facilitate the protein biosynthesis process by interacting with mRNA as well as specialized proteins. Small nuclear RNA (snRNA) is involved in the process of splicing and editing of mRNA molecules, meaning it helps to create the correct mRNA molecule that codes for the desired protein.

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Activity 1 is the graph labeled Brachiopoda, Activity 2 is the graph labeled Mass extinction amongst generas.
1.
(A) Describe the time periods analyzed in Activity 2 that exhibit mass extinctions. Do these time periods correspond to the data analyzed in Activity 1? (Student responses should include references to the figures created in Activities 1 and 2).
(B) Can the extinction rate be equivalent to the origination rate for a group? Describe what would happen to the number of taxa in the group if these rates were equivalent.
(C) Which taxon included in Activity 2 has the oldest origination? Which has the youngest origination? Why does the taxon ‘Trilobita’ not have an origination rate in the Cenozoic era?
(D) Which taxon included in Activity 2 was most diverse at its historical peak?

Answers

A) Time periods analyzed in Activity 2 that exhibit mass extinctions:
The periods of the Late Devonian, Late Permian, Late Triassic, and Late Cretaceous have been found to exhibit mass extinctions.  These periods correspond to the data analyzed in Activity 1 as well.

B) Extinction rate equivalent to the origination rate for a group:
If the extinction rate is equivalent to the origination rate for a group, then the number of taxa in the group would stay the same over time. However, if one rate surpasses the other, then the number of taxa in the group will either rise or decrease, depending on which rate is greater.

C) Oldest and youngest origination of taxon included in Activity 2 and why the taxon Trilobita does not have an origination rate in the Cenozoic era:
The oldest origination of a taxon included in Activity 2 is Brachiopoda, while the youngest origination is Chondrichthyes. The taxon Trilobita does not have an origination rate in the Cenozoic era because they have gone extinct.

D) Taxon included in Activity 2 that was the most diverse at its historical peak:
The taxon included in Activity 2 that was the most diverse at its historical peak is the Brachiopoda, with about 10000 genera identified.

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Which of the following statements is true of the carbohydrate glucose? Remember the difference between stereoisomers and structural isomers.
*
1 point
a) Glucose is a structural isomer of galactose.
b) Glucose is a polysaccharide.
c) Glucose contains carbon, hydrogen, and oxygen atoms.
d)Glucose is a pentose sugar.

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Glucose is a carbohydrate that contains carbon, hydrogen, and oxygen atoms. Among the given options, the true statement about glucose is that glucose contains carbon, hydrogen, and oxygen atoms, i.e., option c.

Glucose is a structural isomer of fructose, not galactose, and is a monosaccharide, not a polysaccharide. Glucose is not a pentose sugar; instead, it is a hexose sugar because it contains six carbon atoms. Glucose is a type of sugar that is a major source of energy for the body's cells. It is the main fuel for the brain, and it is an essential nutrient that must be obtained through food. Glucose can be found in a variety of foods, including fruits, vegetables, grains, and dairy products. It is also produced by the liver when the body needs energy. Glucose is a stereoisomer because it is a type of isomer that has the same molecular formula and sequence of bonded atoms as another molecule but differs in the arrangement of its atoms in space. Among the given options, the true statement about glucose is that glucose contains carbon, hydrogen, and oxygen atoms, i.e., option c.

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Use your textbook (Chapter 4) to complete the following items. are groups of cells similar in structure and perform w common or related 1. Define tisfturiotion. 2. Name the four primary tissue types: epithelial connective muscle , and nervous tissue. 3. On the basis of arrangement or relative number of layers, epithelial tissues are classified as either or 4. On the basis of cell shape, epithelial tissues are classified as or 5. Epithelial tissues are avascular, meaning they have no blood supply. How do they obtain oxygen and nutrients? 6. Where is transitional epithelium found? How does the structure of transitional epithelium relate to its function? 7. The nonliving material between living cells is the and it is a distinguishing characteristic of tissue. 8. The three fiber types found in connective tissue are fibers, fibers, and fibers. 9. What is the name for embryonic connective tissue?

Answers

1. Tissue: Tissue refers to the group of cells that perform the same function.

2. Four Primary Tissue Types: The four primary tissue types are epithelial tissue, connective tissue, muscle tissue, and nervous tissue.

3. Epithelial Tissues: Epithelial tissues are classified on the basis of arrangement or relative number of layers as either simple or stratified.

4. Cell Shape: Epithelial tissues are classified on the basis of cell shape as either squamous, cuboidal, or columnar.

5. Avascular: Epithelial tissues are avascular, meaning they do not have any blood supply. They receive their oxygen and nutrients from the underlying connective tissue.

6. Transitional Epithelium: Transitional epithelium is found in the urinary system. Its structure allows it to stretch and change shape in response to the volume of the urine in the bladder.

7. Nonliving Material: The nonliving material between living cells is called the extracellular matrix. It is a distinguishing characteristic of tissue.

8. Three Fiber Types: The three fiber types found in connective tissue are collagen fibers, elastic fibers, and reticular fibers.

9. Embryonic Connective Tissue: Mesenchyme is the name for embryonic connective tissue.

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each innominate bone is made up of three bones that fuse during the early teen years,

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The innominate bones are each composed of three bones that merge throughout the early teen years.

The three bones that make up the innominate bone are the ilium, ischium, and pubis.The innominate bone, also known as the coxal bone or hip bone, is a large bone that forms the hip’s lateral wall and parts of the pelvis. The hip bone is a complex, thick structure with various features that connect with many other bones, making it an important structure of the body.The ilium is the largest of the three bones that make up the hip bone, and it’s located above the acetabulum. It’s also the most prominent feature of the hip bone, making it a crucial attachment site for various muscles, ligaments, and tendons.The ischium is located below the acetabulum and behind the pubis. It’s the part of the bone that we sit on, making it an important structure for our posture.

It’s also responsible for several attachment sites of muscles and ligaments, making it an important part of our body.The pubis is the front of the hip bone and is located below the ilium and across from the ischium. It’s involved in a variety of attachment sites, such as for the pubic symphysis, which joins both hip bones together, and for the gracilis muscle, which assists in hip adduction. we can say that the innominate bone is a significant bone in the hip that is made up of three bones, which merge together throughout the early teenage years.

These three bones include the ilium, ischium, and pubis. The ilium is the largest of the three bones and is found above the acetabulum, making it a crucial attachment site for several muscles, ligaments, and tendons. The ischium is located below the acetabulum and behind the pubis, and it’s involved in the attachment sites of muscles and ligaments, making it essential in posture maintenance. The pubis is found in front of the hip bone, and it’s important in the attachment sites of the pubic symphysis, which unites both hip bones together, and the gracilis muscle, which helps in hip adduction.

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The Spinal Cord - Spinal nerves The spinal cord is a conducting pathway to and from the brain. 1) What type of information is sent up the spinal cord toward the brain? a) Sensory b) Motor 2) Why is the spinal cord taking it there?

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Sensory information is sent up the spinal cord towards the brain. The spinal cord takes the sensory information up to the brain for processing and interpretation.

The spinal cord is a critical portion of the nervous system that extends from the base of the brain to the lower back. The primary function of the spinal cord is to transmit sensory and motor information between the body and the brain. Specifically, the sensory information advances up the spinal cord towards the brain for processing and interpretation.

This sensory information incorporates perceptions to pain, pressure, temperature and other sensations that are detected by the sensory receptors in the body. The brain then employs this data to establish a perception of the outside world and to reciprocate appropriately.

Contrarily, motor information is sent down the spinal cord from the brain to the rest of the body. This motor information is accountable for controlling voluntary movements and regulating involuntary processes like breathing and heart rate.

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Based on your understanding of separation anxiety, how should a parent respond if their infant screams and refuses to let go of them when presented with staying with a babysitter for the evening?

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Separation anxiety can be defined as a normal developmental phase that can occur in young children between the ages of six months to three years. During this phase, children may feel distressed and anxious when separated from their primary caregiver.

In the scenario where an infant screams and refuses to let go of their parent when presented with staying with a babysitter for the evening, a parent should respond in the following ways:

Stay for a brief period of time: This gives the infant an opportunity to familiarize themselves with the new surroundings and person in their caregiver's absence.

Create a goodbye ritual: For instance, waving or blowing kisses, which can help reassure the infant that the parent is coming back. It is advisable for the parent to keep it short and sweet and leave without lingering. Try not to slip out unnoticed because this can make the infant anxious and confused.

Provide a transitional object: This could be an item such as a blanket, toy, or stuffed animal that can provide comfort to the infant in the parent's absence. It is essential to ensure that the object is safe and not a choking hazard.

Prepare the babysitter: It is vital to provide the babysitter with detailed information about the infant's routine, favorite activities, and cues. This will help the babysitter to provide a supportive and nurturing environment for the infant. Additionally, it is essential to provide the babysitter with relevant emergency contacts, including the parent's contact details.

Finally, it is essential to note that separation anxiety is a normal developmental phase that will eventually pass. Parents and caregivers should provide a supportive and nurturing environment for the infant, which will help ease the separation process.

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Thi correc orcer of disposition process of achemical or xenoblotic is Select one: a. Distribution, absorption, metabolism and excretion. b. Absorption, distribution, metabolism, and excretion. c. Absorption, metabolism, distribution, and elimination. d. Absorption, biotransformation, distribution, and elimination.

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The correct order of the disposition process of a chemical or xenobiotic is:b. Absorption, distribution, metabolism, and excretion.

In the context of pharmacokinetics, this order represents the typical sequence of events that occur after the administration of a chemical or xenobiotic substance.Absorption: This is the process by which the chemical enters the body. It can occur through various routes, such as oral ingestion, inhalation, or dermal absorption.Distribution: After absorption, the chemical is distributed throughout the body via the bloodstream.

It can reach various tissues and organs, including the site of action or target tissues.Metabolism: Metabolism refers to the biotransformation or chemical alteration of the substance in the body. This process is primarily carried out by enzymes in the liver, although other organs may also contribute. Metabolism can involve the conversion of the original substance into metabolites, which may have different pharmacological or toxicological properties.Excretion: Excretion is the elimination of the chemical or its metabolites from the body.

It primarily occurs through urine (renal excretion) but can also involve other routes such as feces, sweat, or exhaled air.Therefore, the correct answer is:b. Absorption, distribution, metabolism, and excretion.

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