As discussed during the lecture, the enzyme HIV-1 reverse transcriptae (HIV-RT) plays a significant role for the HIV virus and is an important drug target. Assume a concentration [E] of 2.00 µM (i.e. 2.00 x 10-6 mol/l) for HIV-RT. Two potential drug molecules, D1 and D2, were identified, which form stable complexes with the HIV-RT.
The dissociation constant of the complex ED1 formed by HIV-RT and the drug D1 is 1.00 nM (i.e. 1.00 x 10-9 mol/l). The dissociation constant of the complex ED2 formed by HIV-RT and the drug D2 is 100 nM (i.e. 1.00 x 10-7 mol/l).
1. Compute the total concentration of [D1]tot that is needed to bind 90% of the HIV-RT at the given concentration [E]tot. Provide your answer as a numerical expression with 3 significant figures in the unit mol/l. You do NOT have to consider competition betwwen the drugs D1 and D2! They are administered separately.
2. Compute the total concentration of [D2]tot that is needed to bind 90% of the HIV-RT at the given concentration [E]tot. Provide your answer as a numerical expression with 3 significant figures in the unit mol/l.You do NOT have to consider competition betwwen the drugs D1 and D2! They are administered separately.

Answers

Answer 1

Answer:

C)[D]/[ED] = 5.20

D)[D]/[ED] = 5.20

E)[D']_T = 1.495* 10 ^-7 M

F)[D'] / [ED']  = 0.0579

Explanation:

E = 250 nM =2.5* 10 ^-7 mol/L , T=298.15 K

Dissociation constant of K_D = 1.3 μM (1.3 *10 ^-6 M)

E + D ⇄ ED → K_a = [ED] / [D][E]   (association constant)

ED ⇄ E + D → K_D = [E][D] / [ED]  (dissociation constant)

C)

[E] =2.5*10^-7 mol/L

K_D = 1.3* 10^-6 M

K_D = [E][D] / [ED] → [D]/[ED] = K_D / [E]

= [D]/[ED] = 1.3* 10 ^-6 / 2.5 *10^-7

= 13/25 * 10

=130/25 = 5.20

[D]/[ED] = 5.20

D)

ΔG =RTln Kd

ΔG_2 for E and D = 1.987 * 298.15 * ln 1.3*10^-6

ΔG_2 592.454 * [ln 1.3 +ln 10^-6]

ΔG_1 = 592.424 [0.2623 - 13.8155]

ΔG_2 = -592.424 * 13.553

ΔG_1 = -8184.633 cal/ mol

ΔG_1 = -8184.633  * 4.18 J/mol = -34244.508 J?mol

ΔG_1 = -34.245 KL/mol

so, ΔG_2 = ΔG_1 - 10.5 KJ/mol

ΔG_2 = -34.245 - 10.5

ΔG_2 = -44.745KJ / mol

ΔG_2 =RT ln K_D

-44.745 *10^3

=8.314 *298.15 lnK_D

lnK_D' = - 44745 / 2478.81 g

ln K_D' = -18.051

K_D' = -18.051

K_D' = e^-18.051

[D]/[ED] = 5.20

E)

[E] = 2.5* 10 ^-7 mol/ L = a

K_D' = [E][D] / [ED']                                  E +D' → ED'

K_D' = a/2(x-(a/2) / (a/2)

KD' = x - a/2

=2.447 *10^-8 = (2.5/2) * 10^-7

x=2.447 * 10^-8 + 1.25 * 10^-7

x = 2.447 *10^-8 + 1.25 * 10 ^-7

x= 10^-7 [1.25 + 0.2447]

x = 1.4947 * 10^-7

[D']_T = 1.495* 10 ^-7 M

F)

K_D' = [E][D'] / [ED']

[D'] / [ED'] = KD' / [E]

[D'] / [ED'] = 1.447 *10^-8 / 2.5* 10^-7

[D'] / [ED'] = 0.5788 * 10^-1

[D'] / [ED']  = 0.0579

Explanation:

...


Related Questions

Alpha particle radiation will most likely result when


electrons gain energy.

atoms become charged.

two atoms are near one another.

the nucleus becomes unstable.

Answers

Answer:

electrons gain energy

Explanation:

Someone answer this please

To convert something in kilojoules to joules, you need to:

Multiply by 1,000
1
Divide by 1,000
2
Multiply by 1,000,000 3
Divide by 1,000,000
4

Answers

Answer:

Divide by 1000

Explanation:

Have a good day

Hope I helped

Multiply by 1000 .

I HOPE IT WILL HELP YOU.

HOPE your day goes great.

A sample of a substance who only oxidizable material is tin in the +2 state, is titrated with a dichromate solution that was prepared by dissolving 1.226g of K₂Cr₂O₇ in enough water to give a volume of 250.00cm³. A 0.0821g sample of the substance required a volume of 23.90cm³ of the titrant to reach the equivalence point . The product of the oxidation of the tin in the +2 state is to tin in the +4 state . The reduction product of the dichromate , is chromium in the +3 state. Calculate the % of tin in the substance . ( NB: Assume the reaction to take place in acidic )​

Answers

Given that, the sample of a substance who only oxidizable material is tin in the +2 state and we are meant to the determine the percentage composition of tin in the substance;

Then, the percentage composition of the tin in the substance is calculated as 172.84%

From the given information:

The molecular weight is the addition of all the atomic masses of a compound.

The molecular weight of K₂Cr₂O₇ is calculated as follows:

= (2 × 39.1) + (2 × 52) + (7 × 16)

= 294.2

The molecular weight of Sn²⁺ = 118.7

The oxidation half-reaction for Tin(ii) ion is as follows:

[tex]\mathbf{Sn^{2+}\to Sn^{4+}+2e^{-}}[/tex]

From the above equation, Tin (ii) ion oxidizes to Tin (iV) ion

The reduction of K₂Cr₂O₇ In the acidic medium, reduce Cr₂ to Chromium Cr³⁺.

[tex]\mathbf{K_2 Cr_2O_7 + 14H^{+}+6e^- \to 2K^+ + 2r^{3+} + 7H_2O}[/tex]

To calculate the percentage % of Tin in the sample, we must first know the Equivalent weight of each substance.

Calculating the equivalent weight (Eq. weight) of each substance in the samples, we have the following:

For K₂Cr₂O₇:

[tex]\mathbf{Eq. weight = \dfrac{molecular \ weight }{numbers \ of \ electrons \ lost \ or \ gained }}[/tex]

[tex]\mathbf{Eq. weight \ of \ K_2Cr_2O_7 = \dfrac{294.2 }{6}}[/tex]

[tex]\mathbf{Eq. weight \ of \ K_2Cr_2O_7 = 49.03 \ g/eq}[/tex]

[tex]\mathbf{Eq. weight \ of \ Sn^{2+} = \dfrac{118.7 }{2}}[/tex]

[tex]\mathbf{Eq. weight \ of \ Sn^{2+} =59.35 g/eq}[/tex]

The next step is to determine the Normality of the Solution.

Normality refers to the mole number per liter of the solution

[tex]\mathbf{Normality \ of \ K_2Cr_2O_7 = \dfrac{1.226 \ g }{49.03}\times \dfrac{1000}{250}}[/tex]

[tex]\mathbf{= \dfrac{4.904}{49.03} N}[/tex]

So, 23.90 mL of  [tex]\mathbf{ \dfrac{4.904}{49.03} N}[/tex] of K₂Cr₂O₇ is required to be present in the solution.

= [tex]\mathbf{=23.90 mL \times \dfrac{4.904}{49.03 } \ of \ Sn \ ion}[/tex]

Thus, the amount of Sn in the sample is calculated as:

[tex]= \mathbf{\dfrac{4.904}{49.03}\times \dfrac{59.35}{1000}\times 23.90 \ mL}[/tex]

= 0.1419 g

Finally, the percentage composition of tIn (Sn) in the sample is:

[tex]\mathbf{= \dfrac{0.1419}{0.0821}\times 100\%}[/tex]

= 172.84%

NOTE: A 0.0821g sample of the substance was given. Ideally, it should be 0.821g. But the calculation was based on the data given.

Therefore, from the above explanation, we can conclude that the percentage % of Sn in the sample is 172.84%

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Please check if that’s right

Answers

Answer:

Explanation:

yes

Tipo completacion. Está formado por un ion metálico y el grupo oh

Answers

Answer: Type complete. It is made up of a metal ion and the group oh

On average an adults lung volume is 5 L convert to mL

Answers

1L=1000mL

[tex]\\ \sf\longmapsto 5L[/tex]

[tex]\\ \sf\longmapsto 5(1000)[/tex]

[tex]\\ \sf\longmapsto 5000mL[/tex]

1. Distinguish between a mixture and a pure substance. ​

Answers

Answer:

1)Mixture is the combination of substance

2)There are two types of mixture such as heterogeneous mixture and homogeneous mixture

3)foreg=Salt solution ,sedimentation

Pure substance

1)Pure substances are also called elements

2)They are made up of small atoms

3)for eg= oxygen,Venadium ,Iron,Oxygen

Help! please i'm kinda stuck in here and i know it's really easy but i literally forgot

Answers

Pretty sure it’s histogram!

Please help me please ​

Answers

Explanation:

1 sugar solution =Distillation

2 Iron powder and sand=magnetic separation

3 petrol and diesel= Fractional distillation

4 Camphor and glass powder = Sublimation

8. Predict the missing products of the double replacement reaction: MgCl2 + Na2S—___+____
a. MgS + NaCl2
b. MgS + NaCl
c. MgNa + CIS
d. MgNa2 + Cl2S

Answers

Answer:

d.MgNa2+Cl2S

Explanation:

the reaction should balance on both sides

Gold can be hammered into decorative gold leaf, which is only 1.00E-07m thick. If 1.35 troy ounce of gold is hammered into gold leaf, what is the area that can be covered when used for decoration? 1 troy ounce = 31.1g, and the density of gold is 19.3 g/cm^3

Answers

The area that can be covered when used for decoration is 21.8 m².

To solve this question, we'll by converting 1.35 troy ounce to grams (g). This can be obtained as as illustrated below:

1 troy ounce = 31.1g

Therefore,

1.35 troy ounce  = 1.35 x 31.1

1.35 troy ounce = 41.985 g

Thus, 1.35 troy ounce is equivalent to 41.985 g.

Next, we shall determine the volume of the gold leaf. This can be obtained as follow:

Mass = 41.985 g.

Density = 19.3 g/cm³

Volume =?

[tex]Density = \frac{mass}{volume } \\\\19.3 = \frac{41.985}{Volume }[/tex]

Cross multiply

19.3 × Volume = 41.985

Divide both side by 19.3

[tex]Volume = \frac{41.985}{19.3}[/tex]Volume = 2.18 cm³

Next, we shall convert 2.18 cm³ to m³.

1 cm³ = 1×10¯⁶ m³

Therefore,

2.18 cm³ = 2.18 × 1×10¯⁶ m³

2.18 cm³ = 2.18×10¯⁶ m³

Thus, 2.18 cm³ is equivalent to 2.18×10¯⁶ m³.

Finally, we shall determine the area. This can be obtained as follow:

Volume = 2.18×10¯⁶ m³

Thickness = 1×10¯⁷ m

Area =?

Volume = Area × Thickness

2.18×10¯⁶ = Area × 1×10¯⁷

Divide both side by 1×10¯⁷

[tex]Area = \frac{2.18*10^{-6} }{1*10^{-7} }\\\\[/tex]Area = 21.8 m²

Therefore, the area that can be covered when used for decoration is 21.8 m²

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Please help me please find the answer ​

Answers

Answer:

look at the pic above

Explanation:

i hope u got it......

In a human nose, the total area of the region that detects our odors is about ¾ in^2. Compare that to the sensory organ of a hunting dog, whose nose has an active area of about 65 cm^2.

Answers

Let it be x

[tex]\\ \sf\longmapsto \dfrac{3}{4}x=65[/tex]

[tex]\\ \sf\longmapsto x=65\times \dfrac{4}{3}[/tex]

[tex]\\ \sf\longmapsto x=\dfrac{260}{3}[/tex]

[tex]\\ \sf\longmapsto x\approx82[/tex]

Outline the main sources of industrial material

Answers

Answer:

In chemistry, an element is a pure substance consisting only of atoms that all have the same numbers of protons in their atomic nuclei. Unlike chemical compounds, chemical elements cannot be broken down into simpler substances by chemical means. Wikipedia

List the steps of the scientific method

Easy points, just don't be annoying.

Answers

Answer:

•1. Make an Observation

•2. Ask a question about ____

•3. Make a hypothesis (educated guess)

•4. Make a hypothesis-based prediction

•5. Test your hypothesis

•6. Graph the results and Iterate.

Answer:

The steps of the scientific method are:-

●Report the Results.

●Ask a Question.

●Test the prediction.

●Make an observation.

●Form a hypothesis, or testable explanation.

●Make a prediction based on the hypothesis.

what is E1 reaction

Answers

Answer:

An elimination reaction is a type of organic reaction in which two substituents are removed from a molecule in either a one- or two-step mechanism. The one-step mechanism is known as the E2 reaction, and the two-step mechanism is known as the E1 reaction0

I Will Mark Brainliest !

Please answer all questions as completely as possible showing all work needed. Also don’t forget to include your units

density = mass / volume
d = m / V

2) Calculate the density of a material that has a mass of 52.457 g and a volume of 13.5 cm3.

3) A student finds a rock on the way to school. In the laboratory he determines that the volume of the rock is 22.7 mL, and the mass in 39.943 g. What is the density of the rock?

4) The density of silver is 10.49 g/cm3. If a sample of pure silver has a volume of 12.993 cm3, what is the mass?

5) What is the mass of a 350 cm3 sample of pure silicon with a density of 2.336 g/cm3?

6) Pure gold has a density of 19.32 g/cm3. What volume would a piece of gold have if it has a mass of 318.97 g?

7) The density of lead is 11.342 g/mL. What would be the volume of a 200.0 g sample of this metal?

8) The mass of a toy spoon is 7.5 grams, and its volume is 3.2 mL. What is the density of the toy spoon?

9) A 28.5 g of iron shot is added to a graduated cylinder containing 45.50 mL of water. The water level rises to the 49.10 mL mark, from this information, calculate the density of iron.

10) A rectangular block of copper metal weighs 1896 g. The dimensions of the block are 8.4 cm by 5.5 cm by 4.6 cm. From this data, what is the density of copper? (Hint: V = l x w x h)



Answers

pray for my test on monday❤️

Which Rocky planet's Biosphere is most different from Earth​

Answers

Answer:

i guess it a right answer for you

Mercury and venus are the two rocky planets that have the atmosphere most, unlike the Earth.

What are rocky planets?

The planets Mercury, Venus, Earth, and Mars, are called terrestrial planets or rocky planets. This is because they have a compact, rocky surface like the Earth's. It's called terra firma.

The terrestrial planets are the four innermost planets in the solar system. These are also called inner planets. The terrestrial planets do not have rings. Earth has belts of trapped radiation.

Among the terrestrial planets, only Earth has a planetary magnetic field that is substantiated. The moons of Mars and the Earth have regional magnetic fields that are localized at various places around their surfaces but they have no global field.

Out of the terrestrial planets, only Venus, Earth, and Mars have significant atmospheres. The atmosphere of mercury is more or less like a vacuum. The gases that are present in a planetary atmosphere are related to the size, mass, temperature, of a planet and the formation of the planet, and about the presence of life.

Therefore, mercury and venus are the two rocky planets that have the atmosphere most, unlike the Earth.

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It's okay to have more than one independent variable in an experiment.
O True
O False

Answers

Answer:

False

Explanation:

I don’t know but I think it’s kinetic?

Answers

The answer is in fact kinetic

Answer:

heat

kinetic

sound

PLS MARK BRAINIEST!!!

tetrachloromethane and water can be seperated using a seperating funnel . what can be reduced from this statement

Answers

Answer: Hello There!................

Separating funnuel. AND

Explanation:

Carbon tetrachloride and water are separated by using a separating funnel. Carbon tetrachloride and water are imiscible with each other. Hence, they form two layers. The density of carbon tetrachloride is more dense than water and forms lower layer. Water being less dense, forms upper layer.

Mark me brainest please. Hope this helps. Anna ♥

Calculate the volume of CO₂ at NTP occupied by 44.4 gram of heat

Answers

We know at NTP each gas has 22.4L of volume .

[tex]\boxed{\sf 1mol\:of\:CO_2=22.4L=44g}[/tex]

Hence 1g of CO2 contain

[tex]\\ \sf\longmapsto \dfrac{22.4}{44}[/tex]

[tex]\\ \sf\longmapsto 0.5L[/tex]

Now 44.4g of CO_2 has

[tex]\\ \sf\longmapsto 0.5\times 44.4=22.2L[/tex]

9.Out of the following which is a poly atomic molecule. (H2, CI 2.03.)​

Answers

the poly atomic molecule is H2

Is baking soda a element, compound or a mixture?

Answers

Answer:

Baking soda (sodium bicarbonate) is scientifically is a compound. It consists of different types of atoms (Sodium, Hydrogen, Carbon, and Oxygen) which chemically combine.

What does the half-life of a radioactive substance indicate?
A. It indicates how dangerous the substance is to humans.
B. It indicates how much energy is released over time.
C. It indicates how long it takes for the material to decay.
D. It indicates how long it takes until all radioactivity is gone

Answers

Answer:

it indicates how long it takes for the material to decay

Explanation:

hope this helps!

The half-life of a radioactive substance indicates how long it takes for the material to decay.

What is half-life of a radioactive?

A half life is the amount of time it takes for half of a radioactive substance to decay.

Radioactive isotopes are defined as the isotopes which undergo decay processes very easily. They have very short half life. They are usually the isotopes of heavier elements.

Half life is defined as the time taken for the unstable isotope to fall to half its original value.

Hence, option C is correct.

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In the laboratory, open-toed shoes and shorts:
a. Are potentially dangerous and should not be worn.
b. Are OK if the weather is hot.
c. Are all right if you are wearing a lab coat
d. Are OK if they are in style.

Answers

Answer:

a. Are potentially dangerous and should not be worn.

How do you write a balanced chemical equation for the reaction of sulfuric acid with magnesium nitrate to form magnesium sulfate and nitric acid

Answers

H2SO4 + Mg(NO3)2 —> MgSO4 + 2HNO3

Select the arrangement that orders the compounds by increasing boiling point based on predominant intermolecular force. Please choose the correct answer from the following choices, and then select the submit answer button. Answer choices N2 < CO2 < NH3 < HF

Answers

The arrangement that orders the compounds by increasing boiling point based on predominant intermolecular force is; N2 < CO2 < NH3 < HF

The molecules that compose a substance are held together by intermolecular forces. The physical properties of a substance such as boiling points depends on the nature of intermolecular forces between substances. The greater the magnitude of intermolecular interaction between bonding atoms the higher the boiling point.

Nitrogen and CO2 molecules are only held together by weak dispersion forces.  However, CO2 has a higher boiling point than N2 because CO2 has a higher molecular mass than N2.

Nitrogen is less electronegative than fluorine hence the magnitude intermolecular interaction via hydrogen bonding in HF is greater than that in NH3 consequently, the boiling point of HF is higher than that of NH3.

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formation of curd from milk is a chemical change

Answers

Answer:

yeah it's a chemical change because..Curd or Dahi is a fermented milk product formed by fermentation of milk by Lactic Acid bacteria to Lactic acid. Milk consists of globular proteins called casein. The curd forms because of the chemical reaction between the lactic acid bacteria and casein. ... The byproduct of ATP production is lactic acid.

hope it helps..stay safe healthy and happy..

why does magnesium donate two electrons to oxygen in order to form magnesium oxide (MgO)?

Answers

Answer:

electron arrangement of Mg is 2.8.2. To reach a stable octet electron arrangement Mg donates 2 electron to oxygen.Hence, Mgo ion formed.

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