Lactose intolerance can be characterized by all of the following except
A. Results from the lack of lactase
B. Can be influenced by the environment
C. Does not involve a persons ability to digest milk
D. Is a good example of bio cultural evolution
E. Has a genetic bases

Answers

Answer 1

Lactose intolerance can be characterized by all of the following except  does not involve a persons ability to digest milk

People with lactose intolerance are unable to fully digest the sugar in milk and as result they have diarrhea and gas and bloating after eating or drinking diary product and the condition which is also called lactose malabsorption and is usually harmless but its symptoms can be uncomfortable and most people with lactose intolerance can manage the condition without having to give up all diary food

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Related Questions

The human body produces 60 billion (60,000,000,000) new cells per day. How many cells does it produce in one hour?

Answers

Answer:

E.g. E. coli—20 min, so in an hour 1 cell would turn into 8.

Given that 60 billion cells are produced in a day in the human body, the number of cells that will be produced in an hour can be calculated by dividing the number of cells by the number of hours in a day. There would be approximately 2.5 billion cells produced in one hour.

How frequently are the cells in our body renewed?

The human body regularly replaces its own cells. Every day, roughly 330 billion cells, or 1% of all our cells are replaced. The equivalent of a new you will have been replenished in 80 to 100 days with 30 trillion.

Each second approximately one million cells of the body die which means 1.2 kg of the cells are destroyed each day. All the cells in the body have a definite lifespan after which they are replenished.

The dead cells of the body are engulfed in a process called phagocytosis and are transferred to the lysosomes where they are degraded.

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D
Why is the second part of
photosynthesis called
"dark" reactions?
A. The reactions cause a dark
pigmentation of the plant.
B. The reactions don't require light to
be carried out. This answer
C. The reactions can't occur in the
dark.
D. The reactions can't occur in the
light.

Answers

Answer:

B. The reactions don't require light to be carried out.

Explanation:

Dark reaction is a light-independent process. This reaction occurs in the stroma of the chloroplast where it utilizes the products of the light reaction. Since this is not directly dependent on light, it is called as the dark reaction.

What surrounds a fertilized
embryo that protects and
nourishes it?
A. a leaf
B. a seed coat this
C. a cone

Answers

Answer:

B that other person was just had a  

weird answer

Explanation:

Answer: B, a seed coat

Explanation:

D. Variation existed in the traits of the fox population. Foxes with smaller ears and noses were able to stay warmer and were more likely to survive and reproduce to pass their genes on to offspring. Over time, the fox population showed a shift to smaller ears and noses.

Answers

The variations in the traits of fox population made them survive more in the cold climate.

What are variations?

Any difference in cells, individuals, or populations of organisms of any species that may be attributed to genetic differences (genotypic variation) or to the influence of environmental conditions on the manifestation of genetic potentials is referred to as variations.Variations in organisms leads to their better adaptations in the adverse climate.

What are adaptations?

Adaptation is the feature of an organism's behavior or physical makeup that enhances the organism's capacity for survival in its environment.

Therefore, variations leads to adaptation of organisms which increases their survival rate. Also the genetic variations are passed on to next generations.

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What is the frequency of a wave if the velocity is 436.1 m/s and the
wavelength is 17.1 meters?

Answers

The frequency of a wave if the velocity is 436.1 m/s and the

wavelength is 17.1 meters is 25.5Hz

What is frequency ?

The quantity of waves that pass a set location in a predetermined period of time is known as frequency. Therefore, if a wave passes through in half a second, the frequency is 2 per second. The frequency is 100 times per hour if it takes 1/100 of an hour.

The temporal rate of change observed in oscillatory and periodic phenomena, such as mechanical vibrations, audio signals (sound), radio waves, and light, is specified by the frequency, an essential parameter in science and engineering.

v = f λ

v = velocity of the wave

f = frequency

λ = wavelength

f = v/ λ =  436.1/17.1 = 25.5 Hz

The frequency of a wave if the velocity is 436.1 m/s and the

wavelength is 17.1 meters is 25.5Hz

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You probably know that you need to breathe oxygen to survive. But how does your body use that oxygen? That oxygen helps your body to release _____ energy that is stored in _____ and other carbon based molecules. The energy is _____ to produce _____. This process of using _____ to produce _____ by breaking down _____ molecules is called _____.

Answers

That oxygen helps your body to release chemical energy that is stored in sugars and other carbon based molecules. The energy is released to produce ATP. This process of using oxygen to produce ATP by breaking down carbon-based molecules molecules is called cellular respiration.

What is cellular respiration?

In Science, cellular respiration can be defined as a series of metabolic chemical reactions that typically occur in both prokaryotic and eukaryotic cells within living organisms, in order to produce energy in the form of adenosine triphosphate (ATP).

Generally speaking, the first step of cellular respiration is a biological and chemical process that is referred to as glycolysis.

In conclusion, we can reasonably infer and logically deduce that all living organisms such as humans, animals, eukaryotes, etc., breathe in oxygen and exhale carbon dioxide in order to survive, which occurs through a process that is referred to as cellular respiration.

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1. Use the diagram of the molecule at the right to answer this question.
The molecule above is made up of only a few different atoms- for each of the atoms listed below tell me how
many of that type of atom there are (just count them up!)
# of Carbon atoms =
# of Hydrogen atoms =
# of Oxygen atoms =
# of Nitrogen atoms =

Answers

According to the diagram the number of No. of Carbon atoms is 9, the number of oxygen atom is 2, the number of hydrogen atom is 9 and the number of nitrogen atom is 0.

The molecule which can be made by the carbon , hydrogen as well as nitrogen atom can be referred as organic molecule.

A complex molecule known as an organic was predominantly bonded carbon atoms joined to other atoms of the same element and/or additional carbon atoms. Each and every living creature on Earth is made up of organic components. Atoms that are bound together form molecules.

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Which of the following groups
of animals could be found in
temperate grasslands?
A. deer, fruit-eating birds, lizards, and snakes
B. bison, longhorns, burrowing animals, birds this
that nest on the ground, and foxes
C. migratory animals, oxen, caribou, and artic
foxes
D. lions, rhinoceros, giraffes, and elephants

Answers

B is the correct answerrree

Which of the following are outcomes due to the creation of synthetic fertilizers?

More food waste
Decreased food production
Less runoff pollution
Poor quality produce

Answers

Answer:

Poor quality produce

Explanation:

Because synthetic fertilizers are man-made,It has higher levels of Nitrogen and phosphorus which causes weak bones, increased diseases of heart and stroke tendency,hence poor quality products when compared with natural fertilizers

You are working at a night clinic as a nurse practitioner and are assessing a 35-year- old male who is complaining of mild-grade fever and a persistent, productive cough that at times appears to have blood. He states he has lost weight in the past 6 months and often wakes up drenched in sweat. He has treated his symptoms with over-the-counter medications but feels that his symptoms are worsening. He had recently traveled to India on business.

Answers

Based on the given symptoms by the patient who is a 35-year- old male who is complaining of mild-grade fever and a persistent, productive cough that at times appears to have blood, he is most likely suffering from rheumatoid arthritis

What is Rheumatoid Arthritis?

This refers to the medical condition that a person can have which can cause them to have pain, swelling, and stiffness in joints as also Fever, fatigue or tiredness, and general body weakness.

Hence, we can see that the patient who complains of these symptoms has said that he has lost weight in the past 6 months and often wakes up drenched in sweat and had recently traveled to India on business, and he should immediately be put on medication and further tests.

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Groups of cells working together form:

Answers

a tissue. Your body has four main types of tissues, as do the bodies of other animals. These tissues make up all structures and contents of your body.

One out of every hundred people of the Hopi Indian tribe inherits the autosomal recessive disease Glucose-6-phosphate deficiency. How many people in the population of six million are carriers of this disease?

Answers

Following the Hardy-Weinberg equilibrium theory, in a population of six million people, 1,080,000 individuals are healthy and carriers (heterozygous) for the trait.

What is the Hardy Weinberg equilibrium?

The Hardy-Weinberg equilibrium is a theory that states that populations in equilibrium get the same allelic and genotypic frequencies generation after generation.

These populations do not evolve. No evolutive forces are acting on them.

Assuming a diallelic gene, frequencies are

Allelic frequencies

p is the dominant allele frequencyq is the recessive allele frequency

Genotypic frequencies

is the frequency of the homozygous dominant individuals is the frequency of the homozygous recessive individuals2pq is the frequency of heterozygous individuals

In a population in equilibrium,

p + q = 1p² + 2pq + q² = 1

We will consider these equations to solve the problem.

Glucose-6-phosphate deficiency is an autosomal recessive disease.One out of every hundred people of the affection. So this is the homozygous recessive genotypic frequency.

Because we have the frequency of the homozygous recessive genotype, we can get the allelic frequency.

= 1/100 = 0.01q = √q² = √0.01 = 0.1

Now, by clearing the equation p + q = 1, we can get the dominant allele frequency. And then, the frequency of the homozygous dominant genotype.

p = 1 - 0.1 = 0.9 = 0.9² = 0.81

Finally, we can get the frequency of the heterozygous genotype

2pq = 2 * 0.9 * 0.1 = 0.18

The number of individuals with each phenotype in the population is,

0.81 * 6,000,000 = 4,860,000 individuals are healthy not carrier0.18 * 6,000,000 = 1,080,000 individuals are healthy carriers. 0.01 * 6,000,000 = 60,000 individuals have the disease.

In a population of six million people, 1,080,000 individuals are healthy and carriers (heterozygous) for the trait.

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Why we can't live without sun?​

Answers

Without the sun there would be no vegetation on earth, because every plant needs light to live and grow. The sun even enables them to generate oxygen by means of photosynthesis, which humans and animals need to breathe. The earth's position in the solar system is optimal for the development of life.

Answer:

If the Sun disappeared or the Earth were flung out of its orbit the travel alone through interstellar space, then I think a small population of humans could survive (although we might need some advance warning).

While the surface of the Earth would freeze and become uninhabitable pretty quickly, there is enough internal heat in the core (left over from the formation of the Earth and generated by radioactive decay) that it would remain warm underground for billions of years. A small population (a few hundred people, maybe) could live in a suitably modified deep mine. With either nuclear power or geothermal power, they could power life support systems and grow food hydroponically. There are enough suitable deep mines for several of those survivor colonies.

Explanation:

examples and non examples of a atom

Answers

Examples: hydrogen
Argon
Iron

Non examples: water
Ozone
Table salt

farmers are aware that chemical fertilizers cause damage to the soil, they still use it because of ?

Answers

I’m guessing but I think because it helps the plants/ fruits and veggies faster

Fertilizers maximize crop yield and increase plant production so, it is used by the farmers in the field.

What are Fertilizers?

Fertilizers are the food for plants which provide nutrients to the plants for growth.  These are the chemical substances which is applied to the crops to increase their yields and production.  It can be of natural or synthetic origin which is applied to soil or to plant tissues to supply plant nutrients.

There are three types of fertilizers which provide the growth to the plants.

1. Nitrogen

2. Phosphorus

3. Potassium

These fertilizers can be used in the field

N, P and K Fertilizers.Micronutrient FertilizersRock PhosphateOrganic Manures.

Thus, fertilizers maximize crop yield and increase plant production so, it is used by the farmers in the field.

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What cellular structure is degenerating and rebuilding in ms

Answers

Answer: Myelin Sheath

Explanation:

In Multiple sclerosis (MS), your immune system attacks the myelin sheath or the cells that produce and maintain it. This attack causes inflammation and injury to the nerve sheath and ultimately to the nerve fibers that it surrounds. The process can result in multiple areas of scarring (sclerosis).

A chemical agent that makes holes in the inner membrane of the mitochondria would:
-stop the movement of electrons down the electron transport chain.
-stop oxidative phosphorylation
-stop the citric acid cycle

Answers

A chemical agent that makes holes in the inner membrane of the mitochondria would stop the movement of electrons down the electron transport chain.

What is Electron?

This is referred to as a subatomic particle and it has a negative charge. It is involved in a chemical reaction when it is either gained, lost or shared thereby forming different types of bonds.

A chemical agent that makes holes in the inner membrane of the mitochondria would stop the movement of electrons down the electron transport chain because of the loss of energy which occurs when  this is done thereby making option A the correct choice.

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The production of ATP in the mitochondria
a. is anaerobic
b. takes place in the outer layer of mitochondria
c. takes place in eukaryotic and prokaryotic cells
d. is directly responsible for beginning the process of making ribosomal RNA
e: requires oxygen

Answers

Answer:

E: Requires oxygen

Explanation:

During respiration, glucose reacts with oxygen to form energy stored as ATP which can later be used by the cell.

the elements are located in certain groups and families based on their

Answers

The elements are located in certain groups and families based on their Similar chemical behavior because they have the same number of valence electrons and similar chemical properties.

Hope this helps :)

10. Which organisms are responsible for spreading the heartworm?

Answers

Infections with the Dirofilaria worm result in the disease known as dirofilariasis. One type, known as "heartworm disease" in dogs, is brought on by D. immitis.

How long can a dog skip a dose of heartworm medication?

If a dose is missed, the majority of monthly heartworm medications provide at minimum 15 days of protection. This implies that even if you are just a week two late, your pet is probably still protected at that period and won't likely contract the infection.

Can people contract heartworms?

Heartworms can occasionally be contracted after already being bitten by an anopheles mosquitoes. However, because humans are not heartworms' natural hosts, the larvae typically move to the arteries and lungs where they die before maturing into adult worms.

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Hemoglobin is a protein that carries oxygen in red blood cells. The hemoglobin molecules produced by some people have one specific amino acid that is different from the amino acid at that position in normal hemoglobin.

Which of the following is the most likely cause of this amino acid variation?

Group of answer choices

The hemoglobin gene contains a mutation.

Enzymes replace the amino acid once the hemoglobin is produced.

An additional amino acid is mistakenly inserted into the hemoglobin during translation.

An error occurs during the folding of the hemoglobin protein.

Answers

Answer:

My best guess is "The hemoglobin gene contains a mutation".

Explanation:

Sorry, I'm not an expert so bear with me!

One more common hemoglobin-related mutation is sickle-cell anemia. It occurs when the amino acid in hemoglobin is substituted from glutamate to valine. It is considered a mutation and is a direct swap from one specific amino acid (glutamate) to a different amino acid (valine) in the same position in the hemoglobin. So, considering that our example (sickle-cell anemia) fits the criteria of swapping one amino acid for another in the hemoglobin, is a mutation, and is passed down genetically (meaning that the hemoglobin gene would need to carry the mutation) it does look a bit like it fits your parameters!

Thus, as I understand it the hemoglobin gene carrying a mutation would make sense as the most likely cause of the amino acid variation.

Again, this is based on 10 minutes of googling. I hope this helps, but apologies if I'm incorrect!! Good luck :)

URGENT
A steroid hormone approaches its target cell. Which will happen first?

The hormone will enter the nucleus
The hormone will combine with proteins to form lipoproteins
The hormone and its receptor will interact with the DNA
The hormone and its receptor will enter the cell’s nucleus

Answers

A steroid hormone approaches its target cell, therefore the hormone will enter the nucleus and is what will happen first which is therefore denoted as option A.

What is a Hormone?

This is referred to as a chemical messenger which is released directly into the bloodstream and is responsible for the control of certain metabolic reactions occurring in the cell and  an example is steroid hormone such as androgens.

In a situation whereby a steroid hormone approaches its target cell, it first passes through the plasma membrane before it then becomes adhered to the receptors which are present in the nucleus or cytoplasm.

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Question 4
When a neuron is not processing information:
O It is negatively charged
O It has no charge
O It is positively charged
O It is sometimes positively charged, sometimes negatively charged

Answers

When a neuron is not processing information It is negatively charged.

The correct option is A.

What is the role of neurons?

Signals are sent and received by neurons, often referred to as nerve cells, from your brain. Although they share many characteristics with other cell types, neurons are physically and functionally distinct. Neurons are able to communicate electrical and chemical messages to other cells via specialised extensions known as axons.

Where are neurons found?

The bulk of neurons in vertebrates are found in the central nervous system, however some are found in peripheral ganglia and many neurones are found in sensory organs like the retina and ear.

What is a neuron made of?

Three basic components make up a neuron: a cell body, two extensions known as an axon, as well as a dendrite (3). The nucleus (2), which regulates the functions of the cell and houses its genetic material, is located inside the cell body. The axon resembles a tail and carries signals out of the cell.

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The complete question is -

When a neuron is not processing information:

A- It is negatively charged

B- It has no charge

C- It is positively charged

D- It is sometimes positively charged, sometimes negatively charged

From a+b-2c take 3a+2b-4c

Answers

The value of the equation illustrated as a+b-2c take 3a+2b-4c is 2c - b.

What is an equation?

An equation is the statement that illustrates the variables given. In this case, two or more components are taken into consideration to describe the scenario. It is vital to note that an equation is a mathematical statement which is made up of two expressions that are connected by an equal sign.

Based on the information, from a+b-2c we are to take away a+2b-4c.

This will be illustrated this:

(a + b - 2c) - (a+2b-4c)

Collect like terms

a + b - 2c - a - 2b + 4c

a - a + b - 2b - 2c + 4c

-b + 2c

= 2c - b

The value is 2c - b.

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Complete question

From a+b-2c take away a+2b-4c

Explain how the prairie is different now from how it was in the past.​

Answers

Answer:

something

Explanation:

Only a small amount of the energy stored in food is available to the next organism in a food chain as a result of which of the following?

Answers

Only a small amount of the energy stored in food is available to the next organism in a food chain as a result of losses to the environment because 90% of energy is lost in the environment as heat.

what is the food chain?

A food chain is described as a linear network of links in a food web starting from producer organisms and ending at an apex predator species, detritivores, or decomposer species.

A food chain also shows how organisms are related to each other by the food they eat.

We know that energy is passed up the food chain from one trophic level to the next but only about 10 percent of the total energy stored in organisms at one trophic level is actually transferred to organisms at the next trophic level. The reason for this is that he rest of the energy is used for metabolic processes or lost to the environment as heat

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describe another situation in which the cell cycle short to allow rapid cell division before returning to normal

Answers

Overexpression of growth factors or the absence of suppressor proteins can lead to rapid cell division.

How the cell cycle allows cell division before returning to normal?

The study of the cell cycle focuses on the apparatus that regulates the timing and frequency of DNA duplication and cell division during the mitotic (M) phase, the cell divides its duplicate DNA and cytoplasm to make two new cells. M phase involves two distinct division-linked processes such as mitosis and cytokinesis. A cell cycle is a series of events that takes place in a cell as it fattens and divides. A cell spends most of its time in what is called interphase, and through this time it grows, replicates its chromosomes, and prepares for cell division. The cell then leaves interphase, undergoes mitosis, and concluded its division.

So we can conclude that the division cycle of most cells comprises four  processes such as cell growth and DNA replication.

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Observe the model below. Explain one strength (advantage) of the model and one limitation (disadvantage).

Answers

The double-stranded structure of DNA guarantees that the genetic information stored in it is difficult to change. However, due to the structure of DNA, it does not replicate as quickly as RNA.

What exactly is the structure of DNA?

DNA has a double-stranded helix structure. Double strands of DNA are made up of complementary strands that run antiparallel to one another. Each strand is made up of nucleotide molecules linked together by phosphodiester linkages.

DNA's double-stranded structure is significant for the following reasons: This guarantees that each strand may be used as a template to produce or copy the genetic information contained in DNA.

It ensures the long-term storage of genetic information in DNA. However, Rna polymerase takes longer than single-stranded RNA replication due to structural differences. Changes in DNA take time as well.

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MItosis:
Takes one cell and replicates it into two genetically identical cells.
Takes one cell and replicates it into two genetically unique cells.
Takes two cells, one from each parent, and replicate it into four genetically unique cells.
Takes one cell and replicates it into four cells, each with half of the original cell's genetic information.

Answers

Answer: hope this helps have a wonderful day

the answers are adcdbcbcacdbc

Explanation: written questions

1. Raul has scraped his knee and noticed that after a week it had almost completely healed. Raul wondered how the skin was able to repair itself while looking exactly the same as his non-injured skin. In 3-5 sentences explain how mitosis plays a role in healing skin after injury and is able to maintain the look of the existing, non-injured skin

Injured skin produces C-rays that allow for skin to knit itself back together. These C-rays are always present in cells, but are only activated during mitosis by injured skin. This is why there is sometimes scarring left after injury, as the C-rays are not activated as much as healing occurs.

2. In three to five sentences, explain the advantage of keeping some DNA needed by mitochondria in the cell’s nucleus and some in the mitochondria itself.

Mitochondrial DNA is the small circular chromosome present inside the cell organelle called mitochondria used for energy production. This type of DNA passes from the mother to the offspring. Mitochondrial DNA (mtDNA) has several advantages over nuclear DNA (nDNA):for species identification purposes including a higher copy number a lack of sequence ambiguities from heterozygous genotypes .a faster rate of mutation

3. In 3–5 sentences, construct a summary of the process of gene expression, starting with DNA and ending with proteins

The process of gene expression starts with the transcription of the genetic information in the DNA into genetic codes in the form of messenger RNA.

The messenger RNA then undergoes some processing such as modification of tails and removal of non-coding sequence before the genetic codes are translated to their respective amino acids in a process known as translation.

The amino acids are linked together by peptide bonds and the resulting primary protein structure is folded in specific ways depending on their functions.

Mitosis takes one cell and replicates it into two genetically identical cells. Thus, the correct option for this question is A.

What is Mitosis?

Mitosis may be defined as a type of cell division through which each parental cell is typically divided into two daughter cells. These daughter cells are genetically identical to the parental cell and are mostly diploid in nature.

On contrary, meiosis is another type of cell division in which each parental cell is divided into four daughter cells which are genetically unique to the parental cell. These daughter cells are haploid in nature. This type of division is known as reductional division. It occurs in the germ cells of organisms.

Therefore, mitosis takes one cell and replicates it into two genetically identical cells. Thus, the correct option for this question is A.

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Which stage of cell cycle does cells divide into 2 cells

Answers

Answer: Cytokinesis

Explanation: P. S. it's not a stage, just the final step.

hope this helps.

During the mitotic (M) phase, the cell divides its copied DNA and cytoplasm to make two new cells. M phase involves two distinct division-related processes: mitosis and cytokinesis.
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If 500j of work is required to carry a charge from one point to another through a potential difference of 20v what is the magnitude of the charge What did the Roman holiday of Lemuralia and the Japanese holiday of Setsubun have in common? How should the impacts of American economic and imperialist growth in the late 19th century be remembered Question 2- Why were three main religious groups fighting over the Holy Land?1. Jew were fighting because they thought that Jesus was killed here and rose fromthe dead.2. Muslims were fighting because they thought that Mohammad died here and rose toheaven3. Christians were fighting because they thought that this was the site of the holytemple built by Abraham4. none of the above leilani has struggled with body distortion for a while. she is so unhappy with how she imagines that she looks that she does not even want to leave the house or hang out with her friends. in fact, if she can avoid being in public, she does. she just wants to stay in her room. what is the best description of the effect that her body distortion is having? The collection of interactions a company has with a customer who has already purchased a product iscalledWhen dealing with customers face-to-face, a good customer service technique istoWhen speaking with customers over the phone, it is important to be aware ofcan change the meaning of what is said. a simply supported beam has a length of 1.2 m. the cross section has a width of 140 mm and height of 240 mm. the weight density of the beam is 5.4 kn/m3 . calculate the maximum permissible value of the load p if (a) the allowable bending stress is 8.5 mpa, and (b) the allowable shear stress is 0.8 mpa. an amendment may be formally proposed only by a the president or the court b congress or national conventions c congress or the president d state conventions or the electorate all of the following strategies may encourage participative management except: select one: a. task delegation. b. parallel suggestion involvement. c. job involvement. d. theory x management. -3x -18 = -6SO MUCH MATH I CANT DO A cube has an edge measuring 7 inches.What is the volume of the cube, in inches? En la Tierra estoy muerto, aunque vivo en la luna. No estoy en un crter, pero estoy en cada flor. No puedo moverme solo, pero estoy en cada habitacin. The temperature on a summer afternoon is 85F. Define a variable and write an expression to find the temperature after it changes. Then evaluate your expression for a decrease of 11 degrees Fahrenheit. What exactly is a Conceptual Model and why is it used? a patient presents to the clinician complaining of ear pain. on examination, the clinician finds that the patient has tenderness on traction of the pinna as well as when applying pressure over the tragus. these findings are classic signs of which condition? marie values the complete protection of her new smartphone more than the $50 per month it would cost her to purchase a comprehensive insurance plan. what should she do? Can someone please solve and explain this for me 8 (x + 2 ) when x = 6 Lolly wrote a total of 10 pages over 5 hours. How many hours will Lolly have to spend writing this week in order to have written a total of 20 pages? a nurse is caring for a client undergoing thyroid hormone therapy for the treatment of multinodular goiter. the client informs the nurse that they are also taking an oral hypoglycemic drug. the nurse would be alert for which possible interaction?