The scientists mapping the SNPs in the human genome noticed that groups of SNPs tended to be inherited together, in blocks known as haplotypes, ranging in length from 5,000 to 200,000 base pairs. There are as few as four or five commonly occurring combinations of SNPs per haplotype. Integrating what you've learned throughout this chapter and this unit, propose an explanation for this observation.

Answers

Answer 1

Answer:

SNPs have shown that only 0.1 % of DNA sequences are different in the human genome between different individuals, thereby all the inherited phenotypic variation observed in our species is associated with only 0.1 % of differences at the genome level  

Explanation:

Haplotypes are block-like sequences of DNA that are inherited together due to low recombination rates. Moreover, single-nucleotide polymorphism (SNP) mapping is a very useful methodology used to map the site of SNP mutations (i.e., SNP variants). In this regard, it has been observed that there are approximately 10 million common SNPs in the human genome. These SNPs contribute to the wide range of phenotypic variation observed in human populations for different traits (e.g., eye color, hair, weight, height, etc). Moreover, researchers have determined that SNPs can be clustered into haplotypes, thereby haplotypes can be accurately sampled by as few as approx. 300,000 selected SNPs, which are sufficient to represent all of the genetic variation across different human genomes.


Related Questions

Which of the following is a risk associated with making our lifestyle more convenient?
Increased use of technology
O Decrease in environmental hazards
Increased use of science
Increased pollution in the air, water, soil

Answers

Answer:

Increased pollution in the air, water, soil.


Choose the appropriate term for each labeled part of
the image.
Label A (ridge core ocean trench)
Label B (ocean trench ridge mantle)
Label C (convection slab pull ridge push)
Label D (convection current slab pull ridge push)

Answers

Answer:

A-b -d d-c c-d

Explanation:

Answer:

Label A

Ocean Trench

Label B

Ridge

Label C

Ridge Push

Labe D

Convection Current

Edg 21

You are a well-trained Cytogenetic Technologist. You work as a Genetic Counselor at a medical institution. You are meeting a nervous couple in your office, who recently found out that they are going to be first-time parents. They have come to you to discuss the chances of having a child with birth defect or genetic disorder. To ease their nerves, you greet them with a smile in your white coat, guide them to their seats, and slowly go through the options of prenatal tests available for them.
KARTOTYPE TEST METHODS
First you introduce to the parents the importance of karyotype test, by describing its domy to detect two broad categories of abnormalities in chromosomes, (1)_____and (2)_____. You provide a few examples of genetic disorders that can be caused by chromosomal abnormalities, such as (3)____and (4)____. Some parents would like to know what is the main cause of these genetic disorders. Without going into too much detail, you explain to them that chromosomal abnormalities are usually caused by (5)____in meiosis I and melosis II, when the homologous chromosomes or sister chromatids fail to separate during meiotic cell division
After the parents have decided to conduct a fetal karyotype test, you collect a small sample of chorion cells through chorionic villi sampling (CVS). Chorion is a membrane around the embryo that eventually fuses with the amnion. The chorion cells are grown in culture because chromosomes are most visible at (6)___stage of cell division. You use a technique called banding to create distinguishable landmarks on the chromosomes. There are several types of staining techniques you can use for karyotyping, some advanced techniques like FISH (fluorescent in situ hybridization) uses fluorescent probes to add colors onto different DNA sequences on the chromosome. You choose the most common type of staining techniques called G- banding to label the fetus chromosomes with Glemsa dye.
After taking photos of the chromosomes from a microscope, you sort the (7)____pairs of autosomes in the following order, from (8)____to (9)____, and keep the sex chromosomes last. The sorted photographed image of chromosomes is called (10)____. Now, you are ready to examine the karyotype of the fetus.

Answers

Answer:

1 monosomy

2 trisomy

3 Down syndrome

4 Turner syndrome

5 non-disjunction

6 metaphase

7 twenty-two

8 largest (chromosome 1)

9 smallest (chromosome 22)

10 karyotype

Explanation:

Non-disjunction during meiosis I or II occur when homologous chromosomes or sister chromatids refuse to separate. This makes the resulting gametes to have too many or too few chromosome numbers in their genomes.

A gamete with too few chromosome number that participates in fertilization with a normal gamete will result in a zygote with abnormally less chromosome number. This situation is referred to as monosomy. Whereas, the fusion of a gamete with too many chromosome number with a normal gamete will result in a zygote with too many chromosome, a situation known as trisomy.

The manifestation of monosomy and trisomy in humans results in Turner and Down syndromes respectively.

Humans have 23 pairs of chromosomes out of which a pair determines maleness or femaleness - the sex chromosome. Other chromosomes are referred to as autosomes. Hence, there are 22 autosome pairs and 1 pair of sex chromosome.

Chromosomes are studied by karyotyping, a process that involves photographing chromosomes at the metaphase stage of the cell cycle, cutting them out, and then arranging them in decreasing order of size.

Which of the following statements is true of cartliage and bone development

Answers

Answer:

Some cartilage becomes bone through ossification during childhood development.

Explanation:

You forgot to include options.

It is observed that constipation is more common among people in the western countries who eat more meat and processed food than us. What could be the reason for this? What should be changed in their diet?
I already know this answer, just checking, it's cuz of roughage

Answers

Answer:

yes your answer is correct

Explanation:

Constipation happens when the colon absorbs too much water, this can occur if the muscles in the colon are contracting slowly or poorly, causing the stool to move too slowly and lose more water. As meat need much water to digest, so they leads to problem of constipation. Hence, they should eat sufficient amount of water to cure constipation.

Constipation is common among people in western countries who eat more meat and processed food because there is no enough roughage in their bodies which prevents constipation .Fruits and vegetables like like corn etc contains lot of roughage.

Answer:

hi here is your answer is that Constipation is common among people in western countries who eat more meat and processed food because there is no enough roughage in their bodies which prevents constipation .Fruits and vegetables like like corn etc cpntain lot of roughage

Explanation:

i hope this answer will help you

The protein calcineurin binds to the protein calmodulin with an association rate of 8.9 × 103 M-1s-1 and an overall dissociation constant, Kd, of 10 nM. The dissociation rate kd is:_____. Please explain step by step.
A. 8.9 × 10^3 M-1s-1
B. 8.9 × 10^2 s-1
C. 1.1 × 10-10 s-1
D. 8.9 × 10-5 s-1

Answers

Answer:

D

Explanation:

From the information given:

Association rate [tex]K_a[/tex] = [tex]8.9 \times 10^3 M^{-1}s^{-1}[/tex]

dissociation constant [tex]K_D[/tex] = 10 nM

dissociation rate [tex]K_d[/tex] = ???

Using the following relation from equilibrium dissociation constant to determine the dissociation rate, we have:

[tex]K_D =\dfrac{ K_d}{K_a}[/tex]

[tex]K_d = K_D \times K_a[/tex]

[tex]K_d =(10*10^{-9} \ M) \times (8.9*10^3 \ M^{-1}{s^{-1})[/tex]

[tex]\mathbf{K_d =8.9*10^{-5} \ {s^{-1}}}[/tex]

Why do you think taking an action or providing measures to prevent disasters ever though you are not experiencing it yet is important?​

Answers

because it not only benefits you but large sums of people as well. it can prevent future disastrous outcomes and doing something even small has a huge impact. instead of having the mentality that it won’t change anything for you, consider how it will change for others and the earth itself

Sickle cell anemia in the United States disproportionately affects African Americans; 1 in 700 African Americans are affected by sickle cell anemia, while only 1 in 160,000 Americans of European descent are affected. The absolute risk of a newborn African American child having sickle cell anemia is ____________%, and the relative risk compared to a newborn European American child is ____________-fold

Answers

Answer:

0.0014; 0.0044

Explanation:

The absolute risk (AR) of a disease refers to the risk of developing the disease over a given time period. In this case, the absolute risk of the newborn African American child having sickle cell anemia is equal to 1 individual with the disease over 700 individuals >> AR = 1 / 700 = 0.0014. Moreover, the Relative Risk (RR) is calculated by comparing the likelihood of the absolute risk occurring between two distinct groups. In this case, the relative risk for the newborn African American having sickle cell anemia compared to a newborn European American child can be calculated by dividing the absolute risk of the newborn European American child with the measured absolute risk of the newborn African American child >> RR = 0.0000625 / 0.0014  = 0.0044.

A part of an mRNA has the sequence CCG. Which change to this sequence
would indicate a missense mutation?
Phe UCC
UUG Leu/UCA
Messenger
Second base in codon
RNA Codons
U
C
A
G
UUU
UCU UAU UGU 1 U
UUC
UAC Tyr
U
UGC)
Cys
с
Ser
UUA
UM Stop UGA Stop A
UCG UAG Stop UGG Trp G
CUU
CCU CAU CGU
CUC ССС
CAC
His
CGC
с
Leu
Pro
CUA CCA
Arg
CAA CGA
Gin
ΓΑ
CUG CCG CAG CGG
AUU ACU
AAU
Asn
AGU
AUC
U
lle ACC ААС AGC
Ser
А
Thr
с
AUA ACA AAA AGA
Lys
AUGS ACG
Α
AAG AGG
GUU GCU GAU GGU
Asp
U
GUC GCC GAC GGC
G
Val Ala
GUA GCA
Gly
GAA
Glu
GGA
GUG) GCG
GAG) GGG)
GCA
First base in codon
OCOCODOC
Third base in codon
Arg
O O A. CCU
O B. CGG
Ос. ССА
D. CCC

Answers

The question is kind of confusing but from what I understand; missense mutations happen when an amino acid is changed to another amino acid. To find out more specifically, look at a codon chart trust me it helps so much lol (just search codon chart and go to images). missense mutations can also cause a premature stop codon so look for a changed amino acid and a stop codon when u look at the codon chart. maybe if u see the different pairs you can get a more specific answer. I hope this helps :)

g 33. Humans are bipedal omnivores (we eat both meat and plants, and we walk upright.) What features of the skull reflect this

Answers

Answer:

Since Skull is the most complete fossil, the features of the skull that reflects Humans as bipedal omnivores are: The teeth and the foramen magnum.

Explanation:

Humans are bipedal because they can move with their two legs, and they are omnivores because of their ability to eat both meat and plants.

The teeth on a skull are the most important indicators of what an animal eats, and it even shows if an animal is a predator or prey. Humans have different sets and shapes of teeth for different purposes making them an example of heterodont dentition.

The pelvis, knee, and foot bones should be the best to tell us about how an animal moves, however, the foramen magnum which opens for the spinal cord to pass to the brain, could also show whether how the animal moved.

Which of the following requires constant agonist-antagonist muscle contractions?
Core integration
Postural development
Dynamic balance
Neuromuscular strength

Answers

Answer:

Postural development

Explanation:

The agonist muscles are sets of muscles responsible for causing joint motion, whereas antagonist muscles are muscles that directly opposite agonist muscles (i.e., antagonist muscles generate an opposing joint torque to the agonist muscles). In a given movement, agonist muscles exhibit concentric contractions while antagonist muscles show eccentric contractions in order to stabilize the joint. Postural development is achieved by concerted adjustments of dorsal muscles and ventral muscles. The dorsal muscles are activated when the body sways forward and the muscle fascicles shorten. During backward sway, these muscles lengthen, while ventral muscles are primarily activated.

Dynamic balance is the condition that requires constant agonist-antagonist muscle contractions.

The agonist-antagonist muscle contraction is the movement where one muscle contracts while the other muscle is relaxing or lengthening. The muscle contracts are agonist whereas the muscle that relaxes is the antagonist here.

Core integration: In such conditions, the constant movement of muscle contraction and relaxation does not require. It is a specific movement and increased stability of the movements.Postural development: continuous development and growth of postural muscles comprising the nervous systemDynamic balance: It would be the ability to balance in motion or changing positions. In this case, muscles require constant both agonist and antagonist contractionsNeuromuscular strength: motor commands according to the central nervous system to the ability to move in the nervous system, hence it does not require constant muscle movements.

Thus, the correct answer is - Dynamic balance.

Learn more about dynamic balance:

https://brainly.com/question/10275827

Do you think that Neanderthals deserve the sometimes negative public image they have?

Answers

Answer:

No.

Explanation:

Neanderthals are portrayed as idiotic animals while in reality they are the beginning of our civilizations. While yes we are far more advanced then they were back then they are still our beginning roots and were smart enough to take the first steps towards advancement causing us to be where we are now :)

Describe a metabolic pathway that is inhibited by the action of a pesticide.

Answers

Explanation:

The mecanism is termed as feedback inhibition.

Explanation:

In an enzyme catalyzed sequential reaction the end product of that reaction inhibits the activity of the activity of the enzyme catalyzing the ist step This type of  regulation is called Feed back regulation or feedback inhibition.

              The main function of human body is to maintain the homeostasis of the all the components it contains.When the end product of an ongoing enzyme catalzsed sequential reaction is produced in a high lebel at that time to maintain its own homeostatis that end product inhibits the functioning of the enzyme catalzsing the ist step of that biochemical reaction.

For Example Cytidine tri phosphate inhibits the activity of aspartate transcarbamoylase catalyzing the de novo biosynthesis pathway of pyrimidine metabolism.

In steps 1, 2, and 3, you will use a Punnett square to predict

Answers

Answer:

I don't get the question.

Explanation:

is it possible that after the first meeting of male and female through sexual inter course
the female become pregnant after the sex??​

Answers

Answer:

Yes, it is possible because, if the sperm from the male goes into the egg of the female it can cause the female to get pregnant by that male. And its very rare for the female not to get pregnant after having inter course with the male. That's only if they had unprotected sex.

I hope this helps you!

XoXo Mashayla

Explanation:

Calculate the fractional saturation for hemoglobin when the partial pressure of oxygen is 78 mm Hg. Assume hemoglobin is 50% saturated with oxygen at a partial pressure of 24 mm Hg and that the Hill coefficient is 3.

Answers

Answer:

YO2 = 0.98

Explanation:

Aspirin may still irritate the stomach as a side effect. What functional group in the molecule is responsible for this effect

Answers

Answer:

The functional group that irritates the stomach is known as the salicylic acid molecule.

Explanation:

What type of lipid is shown?
saturated
unsaturated
phospholipid
triglyceride

Answers

Answer:

unsaturated is the correct answer

In algae and plants, photosynthesis happens in the
vacuoles.
mitochondria.
chloroplasts.
chromosomes.

Answers

Answer:

chloroplast........................

Answer:

chloroplasts

Explanation:

they contain chlorophyll, a necessary element for photosynthesis

does tomato have thick or thin exocarp?​

Answers

I think it’s thick

Explanation
Here, we describe the simultaneous transcriptome profiling of all five major cell types/tissues of the tomato fruit pericarp (Figure 1), including the outer epidermis (a single cell layer), collenchyma (approximately three to five cell layers in the Ailsa Craig cultivar used in this analysis), parenchyma

Note that arteries have a thicker middle layer of tissue than veins. Why is this important and how does it affect the structure of the artery as compared to the vein?

Answers

Answer:

The correct answer is - To withstand the high pressure of the outflow of blood from the Heart.

Explanation:

The heart pumps blood to different body parts at high pressure so that it can easily reach all the parts of the body quickly. To able to hold the pressure of the blood pumped at high-pressure arteries need thick walls.

This pressure can be experienced as pulse and which required the walls of arteries and the middle layer or the tunica media to make it much thicker in arteries than in veins. In veins pressure caused by blood is very low pressure that allows them to be thin walls.

Use the Hide Others button to hide the other structures in the view and observe the routes of the arteries. Select the largest artery, traveling from the heart downward through the torso. What is this artery called

Answers

Answer:

The correct answer is - Aorta or descending aorta.

Explanation:

The main artery carries blood from the left ventricle of the heart to the rest of the body and going downwards in the torso is the aorta. The blood leaves the heart through the aortic valve making a cane-shaped curve that allows other major arteries to deliver oxygen-rich blood to the brain, muscles, and other cells. It is known as the largest artery of the human body.

The correct answer is - Aorta or descending aorta.

Summarize the steps of Scientific method in one paragraph in your own words.

Answers

Answer:

Ask a question or identify a problem.Gather information and form a hypothesis.Create an experiment to test your hypothesis.Collect data and observations by doing/ performing the experiment. Draw a conclusion.Share your findings.

If you want as paragraph:

Ask a question or identify a problem. Gather information and form a hypothesis. Create an experiment to test your hypothesis. Collect data and observations by doing/ performing the experiment. Draw a conclusion. Share your findings.

Hope it helps!

Plz mark brainliest!

Which of the following could be a characteristic of the fossil that is most closely related to humans? S-shaped back bo...

Answers

Answer: S-shaped back bo

Explanation: That was the only choice

Answer:

S-shaped back bone

Explanation:

pls mark as brainlists

Describe the normal process of osteogenesis for compact and spongy bone using the three different types of bone cells and their functions

Answers

Answer:

Osteoblasts penetrate the disintegrating cartilage and replace it with spongy bone. This forms a primary ossification center. Ossification continues from this center toward the ends of the bones. After spongy bone is formed in the diaphysis, osteoclasts break down the newly formed bone to open up the medullary cavity.

explain water cycle with the help of diagram​

Answers

Explanation:

The water cycle is defined as a natural process of constantly recycling the water in the atmosphere. It is also known as the hydrological cycle or the hydrologic cycle. During the process of the water cycle between the earth and the atmosphere, water changes into three states of matter – solid, liquid and gas.

hope it helps.stay safe healthy and happy...

what are the difference between DNA and RNA​

Answers

Answer:

There are two differences that distinguish DNA from RNA: (a) RNA contains the sugar ribose, while DNA contains the slightly different sugar deoxyribose (a type of ribose that lacks one oxygen atom), and (b) RNA has the nucleobase uracil while DNA contains thymine.

The extinction vortex represents the idea that even if an organism is extant, it may have a gene pool that will not support its long-term survival.A. TrueB. False

Answers

Answer:

True.

Explanation:

Extinction vortex is a model used by scientists to understand extinction dynamics within a community. This model allows scientists to assess and understand how a population can become highly vulnerable to elements of its habitat, becoming increasingly apt for extinction. According to this model, any organism is capable of extinction, as all are susceptible to having a gene pool that will not allow its survival, regardless of the environment.

explain what makes psychology a science.

Answers

Psychology is a science because it follows the empirical method. ... We can directly observe and carefully measure externals such as what a person does, says, and marks down on a psychological test. We cannot directly observe a person's mind (e.g., internal thoughts, emotions).

In a diploid cell, a FISH probe should produce ____________ signals in metaphase FISH and ____________ signals in interphase FISH.

Answers

Answer: Four, two

Explanation:

FISH (fluorescence in situ hybridization) is a technique for chromosome mapping with probes that emit fluorescence and allow the visualization, distinction and study of chromosomes of nuclei in metaphase or inferophase. In this way, any type of anomaly such as inversions, aneuploidies, duplications or microdeletions can be seen. To do this, a non-specific DNA staining is performed with DAPI (a fluorophore that marks the nucleus where DNA is present) and the fluorescence will be seen under the microscope.

When cells are in metaphase, their chromosomes are condensed in preparation for cell division. To stop them in metaphase, colchicine is used which is a microtubule depolymerizing agent responsible for separating the sister chromatids of a chromosome, thus preventing the progression of cell division and arresting the cell cycle in metaphase. Here we will see translocations, microdeletions or duplications.

Interphase FISH is used to see decondensed chromatin, which allows higher resolution in detecting small abnormalities. It is mainly used for the detection of aneuploidies or large deletions, duplications or translocations when samples are difficult to grow or are scarce, as in the case of fetal or tumor cells. It is not possible to distinguish between a normal karyotype and a karyotype showing a balanced translocation. In addition, it can be used in the analysis of solid tumors, which divide very infrequently.

During metaphase, the chromosomes are duplicated so there would be two sets of chromosomes (a total of four chromosomes). Then, there would be four signals for each probe. During interphase, the chromosomes are not dupicated. Since it is a diploid organisms, there would be two chromosomes and this will represen two signals for probe.

Other Questions
What is the theme of Ovids The Story of Daedalus and lcarus? Based on the passage, the reader can infer that ______ would have been a consequence of inflation in Rome.a. The poor became wealthy citizens as they benefitted from more valuable coins.b. It led to unrest as the citizens struggled to meet the rising price of goods.c. Inflation caused the emperor to begin to give out free food to the people of Rome.d. It caused rich people in Rome to lose their wealth because they gave much of it to the poor. 4. In Act One, juror three has an outburst about his own child and their relationship. After his outburst, the stagedirections in the play indicate that he is embarrassed. Why might juror three be embarrassed about what he hasjust said? identify the volume of a sphere if it has a surface area of 465 square units 7. The message on a diamond-shaped sign might bea. Pass With Care, Trucks Use Right Lane, orDo Not Pass.b. Curve, Hill, or Winding Road.One Way, Wrong Way, or No Trucks.d. No Turn, Speed Zone Ahead, or Left LaneMust Turn Left. what are the core differences between HRD and HRMM? write in four points. Exercise 4-11 Computing net sales for multiple-step income statement LO P4 A company reports the following sales-related information. Sales, gross $ 245,000 Sales returns and allowances $ 20,000 Sales discounts 4,900 Sales salaries expense 10,900 Prepare the net sales portion only of this companys multiple-step income statement. The Prime Minister's statements are considered to be the view of the whole country. Explain! help me please!!!!!!!! Deviance often leads to social change. What may be seen as disruptive, problematic behavior at one moment, might later be recognized as a brave statement against injustice. The idea that small groups of people can reshaped societal norms and values is exemplified by the __________ . The perimeter of a square is 80cm state the length of one of its side population education is also called asSubject for population awarness. Why? Which of the following statements should be included in a summary of the subsection Saving the Bees?Your answer:a.Use organic products to treat plants at night.b.Both lawmakers and regular people have important roles in helping to save the bees.c.France is the most bee friendly country in the nation.d.Planting trees is better than planting flowers all year long. The following adjusted trial balance is the result of the adjustments made at the end of the month of July for Ladonna Douglas Corporation.Ladonna Douglas CorporationADJUSTED TRIAL BALANCEJuly 31, 20--ACCOUNT TITLE DEBIT CREDITCash 34,750.00 Accounts Receivable 9,750.00 Office Supplies 2,525.00 Store Supplies 4,785.00 Machinery 10,750.00 Accumulated Depreciation 2,150.00Accounts Payable 14,300.00Notes Payable 11,500.00Common Stock 33,725.00Retained Earnings 20,000.00Dividends 13,250.00 Service Revenue 41,500.00Wages Expense 37,425.00 Rent Expense 3,000.00 Advertising Expense 2,750.00 Office Supplies Expense 1,465.00 Store Supplies Expense 2,150.00 Depreciation Expense 575.00 Totals 123,175.00 123,175.00Required:Utilize these adjusted values to perform the closing entries for Ladonna Douglas Corporation. Simplify by expressing fractional exponents instead of radicals. Which statement is the best description of a chemical bond Determine the dimensions of the rectangle of largest area that can be inscribed in a semicircle of radius 4 Meaning of the idiom, "dressed up to the nines" Mandira is not patient at all. [Remove not] PH Find the expected value of the winnings from a game that has the following payout probability distribution: 1 2 Payout ($) 0 5 10 0.1 Probability 0.12 0.2 0.38 0.2 Expected Value = [?] Round to the nearest hundredth.